Cataloguing and characterizing interests in typically developing toddlers and toddlers who develop ASD.

Cataloguing and characterizing interests in typically developing toddlers and toddlers who develop ASD.
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DOI:
10.1002/aur.2543
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发表时间:
2021-08
期刊:
Autism research : official journal of the International Society for Autism Research
影响因子:
--
通讯作者:
IBIS Network
IBIS Network
中科院分区:
其他
文献类型:
--
作者:
Burrows CA;Bodfish JW;Wolff JJ;Vollman EP;Altschuler MR;Botteron KN;Dager SR;Estes AM;Hazlett HC;Pruett JR Jr;Schultz RT;Zwaigenbaum L;Piven J;Elison JT;IBIS Network

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强烈的兴趣在患有和没有自闭症谱系障碍(ASD)的儿童中很常见,并且很少有研究描述了患有和没有ASD的儿童之间独特或共享的兴趣方面。我们的目的是使用一种新的访谈来描述ASD高家族风险(HR)和低家族风险(LR)婴儿样本的兴趣。参与者包括24个月时被诊断为ASD的HR兄弟姐妹(HR-ASD,n=56),24个月时未接受ASD诊断的HR兄弟姐妹(HR-Neg,n=187)和LR对照组(n=109)。我们开发并收集了18个月和24个月大时的强烈兴趣清单数据,这是一个半结构化的访谈,可以测量幼儿和学龄前儿童的兴趣强度和特殊性。在24个月时,兴趣强度因家族风险而异,HR-ASD和HR-Neg组表现出相同的兴趣强度,高于LR组。相比之下,ASD诊断的特殊性不同,HR-ASD组在24个月时比HR-Neg和LR组显示出更多的特殊兴趣。18个月时,HR-ASD组比LR组有更多特殊的兴趣,尽管兴趣强度没有差异。这项措施可能是有用的,在确定临床相关的功能,在幼儿ASD的利益。我们还复制了先前的研究结果,即在我们的非ASD样本中,男性在18个月时表现出更强烈的兴趣。这些结果揭示了新的信息的性质的利益和关注的早期自闭症表型。强烈的兴趣在自闭症儿童及其家庭成员中很常见。强烈的兴趣也普遍存在于典型的发展中的儿童,尤其是男孩。在这里,我们目录的利益和这些利益的特点,在一个大样本的幼儿丰富的自闭症风险。有自闭症家庭成员的孩子有更强烈的兴趣,而那些自己患自闭症的孩子在24个月时有更多不寻常的兴趣。这些结果突出了自闭症不同方面兴趣的重要性。
Intense interests are common in children with and without autism spectrum disorder (ASD), and little research has characterized aspects of interests that are unique to or shared among children with and without ASD. We aimed to characterize interests in a sample of infants at high-familial-risk (HR) and low-familial-risk (LR) for ASD using a novel interview. Participants included HR siblings who were diagnosed with ASD at 24 months (HR-ASD, n=56), HR siblings who did not receive an ASD diagnosis at 24 months (HR-Neg, n=187), and a LR comparison group (n=109). We developed and collected data with the Intense Interests Inventory at 18- and 24-months of age, a semi-structured interview that measures intensity and peculiarity of interests in toddlers and preschool-aged children. Intensity of interests differed by familial risk at 24 months, with HR-ASD and HR-Neg groups demonstrating equivalent intensity of interests that were higher than the LR group. By contrast, peculiarity of interest differed by ASD diagnosis, with the HR-ASD group showing more peculiar interests than the HR-Neg and LR groups at 24 months. At 18 months the HR-ASD group had more peculiar interests than the LR group, though no differences emerged in intensity of interests. This measure may be useful in identifying clinically-relevant features of interests in young children with ASD. We also replicated previous findings of males showing more intense interests at 18 months in our non-ASD sample. These results reveal new information about the nature of interests and preoccupations in the early autism phenotype. Intense interests are common in young children with autism and their family members. Intense interests are also prevalent among typically-developing children, and especially boys. Here we catalogue interests and features of these interests in a large sample of toddlers enriched for autism risk. Children who had family members with autism had more intense interests, and those who developed autism themselves had more unusual interests at 24 months. These results highlight the importance of different aspects of interests in autism.
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