Anxiety and depression among outpatients with type 2 diabetes: A multi-centre study of prevalence and associated factors.
Anxiety and depression among outpatients with type 2 diabetes: A multi-centre study of prevalence and associated factors.
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DOI：
10.1186/1758-5996-2-72
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发表时间：
2010-12-20
影响因子：
4.8
通讯作者：
White F
中科院分区：
文献类型：
--
作者：
Khuwaja AK;Lalani S;Dhanani R;Azam IS;Rafique G;White F
焦虑和抑郁导致糖尿病患者的疾病结局不佳。本研究旨在评估焦虑和抑郁的患病率，并确定其相关因素，包括2型糖尿病患者的代谢成分。我们在巴基斯坦卡拉奇的四个门诊诊所进行了一项横断面、多中心研究。总共有889名2型糖尿病成年人被纳入这项研究。采用医院焦虑抑郁量表（HADS）测量焦虑和抑郁。采用多元Logistic回归进行多变量分析，以评估与焦虑和抑郁相关的各种因素的综合影响，同时调整混杂变量。总体而言，57.9%（95% CI = 54.7%，61.2%）和43.5%（95% CI = 40.3%，46.8%）的研究参与者分别有焦虑和抑郁。与焦虑独立相关的因素是缺乏运动、高血压和缺血性心脏病。对于抑郁症，女性，年龄较大，患有高血压和缺血性心脏病显着相关。发现与焦虑和抑郁独立相关的代谢成分是收缩压、空腹血糖和空腹甘油三酯。体重指数与抑郁症独立相关，但与焦虑无关。这项研究发现，很大一部分成年糖尿病患者患有焦虑和/或抑郁症，并确定了与这些实体相关的因素。这些结果提醒临床医生将焦虑和抑郁作为糖尿病护理的常见组成部分进行识别和治疗。需要进行更多的研究，以确定这种关系的方向性，并测试干预措施。
Anxiety and depression contribute to poor disease outcomes among individuals with diabetes. This study aimed to assess the prevalence of anxiety and depression and to identify their associated factors including metabolic components among people with type 2 diabetes. We conducted a cross-sectional, multi-center study in four out-patient clinics in Karachi, Pakistan. In all, 889 adults with type-2 diabetes were included in this study. Anxiety and depression were measured by using the Hospital Anxiety and Depression Scale (HADS). Multivariable analysis using multiple logistic regression was carried out to evaluate the combined effect of various factors associated with anxiety and depression, while adjusting for confounding variables. Overall, 57.9% (95% CI = 54.7%, 61.2%) and 43.5% (95% CI = 40.3%, 46.8%) study participants had anxiety and depression respectively. Factors found to be independently associated with anxiety were physical inactivity, having hypertension and ischemic heart disease. For depression, being female, of older age, having hypertension and ischemic heart disease were significantly associated. Metabolic components found to be independently associated with both anxiety and depression were systolic blood pressure, fasting blood glucose and fasting blood triglycerides. Body mass index was independently associated with depression but not with anxiety. This study identified that a large proportion of adults with diabetes had anxiety and/or depression, and identified factors associated with these entities. These results alert clinicians to identify and treat anxiety and depression as common components of diabetes care. Additional studies are needed to establish the directional nature of this relationship and to test interventions.
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影响因子：
6.7
作者：
Hildrum, B.;Mykletun, A.;Dahl, A. A.
通讯作者：
Dahl, A. A.
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Russo, JE
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Caspi, Avshalom
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16.2
作者：
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通讯作者：
Simpson, K
影响因子：
105.7
作者：
Mirza, I;Jenkins, R
通讯作者：
Jenkins, R