An exploratory randomized sub-study of light-to-moderate intensity exercise on cognitive function, depression symptoms and inflammation in older adults with heart failure.
An exploratory randomized sub-study of light-to-moderate intensity exercise on cognitive function, depression symptoms and inflammation in older adults with heart failure.
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DOI：
10.1016/j.jpsychores.2019.109883
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发表时间：
2020-01
影响因子：
4.7
通讯作者：
Hurwitz B
中科院分区：
文献类型：
--
作者：
Redwine LS;Pung MA;Wilson K;Bangen KJ;Delano-Wood L;Hurwitz B
几乎一半的心力衰竭（HF）患者有认知障碍。虽然运动与更好的认知健康有关，但心衰的一个标志是运动不耐受。研究目的是探讨轻度至中度运动是否能改善心衰患者的认知功能。方法：这是一项探索性平行设计研究，从VA和加州大学圣地亚哥分校医疗系统招募了69例有症状的HF患者（平均年龄=65,SD = 10）。参与者被随机分为太极（TC） （n = 24）、阻力带（RB）运动（n = 22）或常规治疗（TAU） （n = 23）。主要结果是蒙特利尔认知评估（MoCA）评分的变化。我们进一步探讨了贝克抑郁量表-IA （BDI-IA）评分或炎症生物标志物、CRP、TNFα和IL-6的变化是否与认知功能改变有关。结果：组间MoCA评分变化有固定效应（F = 8.07, p = .001）。与TAU相比，TC组和RB组MoCA评分增加更大，但TC组和RB组之间没有差异。抑郁症状的改变预测MoCA评分的改变（ΔR2 = 0.15， Δ =−）。413, p = .001)。然而，在MoCA改变方面，组与抑郁症状水平没有相互作用（p = .392）。CRP水平的变化预测MoCA评分（ΔR2 = 0.078， Δ =−）。283, p = 0.01)，但c反应蛋白水平对MoCA的改变没有相互作用（p = 0.689）。结论：轻至中度运动、TC和RB可改善认知功能。然而，其机制尚不清楚。ClinicalTrials.gov: NCT01625819
Almost half of patients with heart failure (HF) have cognitive impairment. While exercise relates to better cognitive health, a hallmark of HF is exercise intolerance. The study objective was to explore whether light-to-moderate exercise improves cognitive function in patients with HF. Methods: This was an exploratory parallel design study of 69 patients with symptomatic HF (mean age=65, SD = 10), recruited from VA and University of California, San Diego Healthcare Systems. Participants were randomized to Tai Chi (TC) (n = 24), resistance band (RB) exercise (n = 22) or treatment as usual (TAU) (n = 23). The primary outcome was change in Montreal Cognitive Assessment (MoCA) scores. We further explored if changes in Beck Depression Inventory – IA (BDI-IA) scores or inflammation biomarkers, CRP, TNFα and IL-6 related to altered cognitive function. Results: There was a fixed effect of group for MoCA scores changes (F = 8.07, p = .001). TC and RB groups had greater MoCA score increases versus TAU, but no differences were found between TC and RB. Depression symptom changes predicted altered MoCA scores (ΔR2 = .15, Δ = −.413, p = .001). However, group did not interact with depression symptom levels for MoCA alterations (p = .392). Changes in CRP levels predicted MoCA scores (ΔR2 = .078, Δ = −.283, p = .01), but group did not interact with CRP levels for MoCA alterations (p = .689). Conclusions: Light-to-moderate exercises, TC and RB may improve cognitive function. However, the mechanisms remain unclear. ClinicalTrials.gov: NCT01625819
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