Edible marijuana and cycle ergometer exercise.
Edible marijuana and cycle ergometer exercise.
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DOI：
10.3389/fphys.2022.1085822
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发表时间：
2022
影响因子：
4
通讯作者：
Bell, Christopher
中科院分区：
文献类型：
--
作者：
Ewell, Taylor Russell;Bomar, Matthew Charles;Abbotts, Kieran Shay Struebin;Butterklee, Hannah Michelle;Dooley, Gregory P.;Bell, Christopher
目的：公众和科学界对大麻和精神活性大麻素δ-9-四氢大麻酚（THC）对运动表现的影响有着广泛的兴趣。不幸的是，缺乏最近的最新研究。本研究的目的是解决这一假设，即在运动前摄入食用大麻会对运动的生理反应和运动表现产生不利影响。 方法：17名健康成年男性和女性习惯性锻炼者，他们是大麻产品的经常使用者，被筛选参与研究。入组了10例患者，保留了9例患者的数据[8例男性，1例女性，年龄25±3岁，峰值摄氧量为56.5±11.7 ml/kg/min（平均值± SD）]。参与包括两次运动，每次运动之前都要自我管理和摄入食用大麻（含有10毫克THC）或安慰剂。在完成20分钟功能阈值功率测试（FTP 20）和涉及最大努力直至意志疲劳的冲刺测试之前，记录对固定自行车测力计运动（50、100和150 W下8分钟）的心肺反应（通过间接量热法）。 结果如下：食用大麻增加了循环THC和THC代谢物的浓度，并引起了中毒和改变精神状态的感觉。对阶段性自行车运动的呼吸反应是正常的，不受食用大麻的影响。与安慰剂相比，食用大麻不影响FTP 20（安慰剂：253±75 vs THC：251±72 W（平均值±SD）; p > 0.45）或冲刺测试期间的峰值功率输出（安慰剂：710±201 vs THC：732±136 W; p = 0.864）。 结论：10毫克的THC，当摄入运动前的定期锻炼者和习惯性用户的大麻，对生理反应的标准化自行车测力计运动几乎没有影响，既不是ergogenic也不是ergolytic。
Purpose: There is extensive public and scientific interest in the influence of cannabis and the psychoactive cannabinoid, delta-9-tetrahydrocannabinol (THC), on exercise performance. Unfortunately, recent, up-to-date studies are lacking. The aim of the current study was to address the hypothesis that ingestion of edible marijuana, prior to exercise, would have unfavorable effects on the physiological response to exercise and on exercise performance. Methods: 17 Healthy adult male and female habitual exercisers, who were regular users of cannabis products, were screened for study participation. 10 were enrolled, and data from 9 [8 males, 1 female, aged 25±3 years, with peak oxygen uptake of 56.5±11.7 ml/kg/min (mean ± SD)] were retained. Participation included two exercise sessions, each preceded by self-administration and ingestion of either edible marijuana (containing 10 mg THC) or placebo. Cardio-respiratory responses (via indirect calorimetry) to stationary cycle ergometer exercise (8 min at 50, 100 and 150 W) were recorded before completion of a 20-min Functional Threshold Power test (FTP20) and a sprint test involving maximal effort until volitional fatigue. Results: Edible marijuana increased the concentration of circulating THC and THC metabolites, and evoked sensations of intoxication and altered psychoactive state. Cardio-respiratory responses to staged cycle ergometer exercise were normal and were unaffected by edible marijuana. Compared with placebo, edible marijuana did not influence FTP20 (Placebo 253±75 vs THC: 251±72 W (mean±SD); p > 0.45) or peak power output during the sprint test (Placebo: 710±201 vs. THC: 732±136 W; p = 0.864). Conclusion: 10 mg of THC, when ingested prior to exercise by regular exercisers and habitual users of cannabis, had little effect on the physiological response to standardized cycle ergometer exercise, and was neither ergogenic nor ergolytic.
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影响因子：
3.6
作者：
Kirk, JM;de Wit, H
通讯作者：
de Wit, H
DOI：
10.1249/00005768-198205000-00012
发表时间：
1982-01-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
BORG, GAV
通讯作者：
BORG, GAV
影响因子：
3.3
作者：
FORSTER, HV;DEMPSEY, JA;THOMSON, J
通讯作者：
THOMSON, J
DOI：
10.3390/ph14080817
发表时间：
2021-08-20
期刊：
Pharmaceuticals (Basel, Switzerland)
影响因子：
--
作者：
Ewell TR;Abbotts KSS;Williams NNB;Butterklee HM;Bomar MC;Harms KJ;Rebik JD;Mast SM;Akagi N;Dooley GP;Bell C
通讯作者：
Bell C
影响因子：
3.8
作者：
通讯作者：
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