Control of organ growth by patterning and hippo signaling in Drosophila.
Control of organ growth by patterning and hippo signaling in Drosophila.
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DOI：
10.1101/cshperspect.a019224
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发表时间：
2015-06-01
影响因子：
7.2
通讯作者：
Harvey KF
中科院分区：
文献类型：
--
作者：
Irvine KD;Harvey KF
器官大小的控制是至关重要的，并且受遗传、环境和机械因素控制。在许多物种中的研究已经指出存在器官-外在和器官-内在大小控制机制，最终必须协调以调节器官大小。在这里，我们讨论器官的大小控制器官模式和河马途径，这两个作用在器官内在的方式。形态发生素和其他模式化分子的影响将生长和模式化结合在一起，而新出现的证据表明，Hippo通路响应于机械刺激和细胞间相互作用发出的信号来控制生长。据报道，在膜受体和转录调节因子的水平上，控制器官模式的信号通路和Hippo通路之间存在几个串扰点。然而，尽管在过去十年中取得了实质性进展，但生长控制领域的关键问题仍然存在，包括器官模式和Hippo通路如何以及何时沟通以控制大小，以及这些沟通机制是器官特异性的还是一般的。此外，阐明器官内在线索（如模式因子和Hippo通路）与外在线索（如激素）相互作用以控制器官大小的机制仍未得到解决。
Control of organ size is of fundamental importance and is controlled by genetic, environmental and mechanical factors. Studies in many species have pointed to the existence of both organ-extrinsic and organ-intrinsic size control mechanisms, which ultimately must coordinate to regulate organ size. Here we discuss organ size control by organ patterning and by the Hippo pathway, which both act in an organ-intrinsic fashion. The influence of morphogens and other patterning molecules couples growth and patterning, whilst emerging evidence suggests that the Hippo pathway controls growth in response to mechanical stimuli and signals emanating from cell-cell interactions. Several points of crosstalk have been reported between signalling pathways that control organ patterning and the Hippo pathway, both at the level of membrane receptors and transcriptional regulators. However, despite substantial progress in the past decade, key questions in the growth control field remain, including precisely how and when organ patterning and the Hippo pathway communicate to control size and whether these communication mechanisms are organ-specific or general. In addition, elucidating mechanisms by which organ-intrinsic cues such as patterning factors and the Hippo pathway interface with extrinsic cues such as hormones to control organ size remains unresolved.
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影响因子：
2.7
作者：
BRYANT, PJ;LEVINSON, P
通讯作者：
LEVINSON, P
果蝇F-box蛋白FBXL7与原粘蛋白脂肪结合，并调节DACHS定位和河马信号传导。
影响因子：
7.7
作者：
Bosch JA;Sumabat TM;Hafezi Y;Pellock BJ;Gandhi KD;Hariharan IK
通讯作者：
Hariharan IK
DOI：
10.1016/j.cub.2010.02.035
发表时间：
2010-04-13
期刊：
Current biology : CB
影响因子：
--
作者：
Das Thakur M;Feng Y;Jagannathan R;Seppa MJ;Skeath JB;Longmore GD
通讯作者：
Longmore GD
影响因子：
7.3
作者：
Baena-Lopez LA;Franch-Marro X;Vincent JP
通讯作者：
Vincent JP
影响因子：
9.2
作者：
Bennett, F. Christian;Harvey, Kieran F.
通讯作者：
Harvey, Kieran F.