CNS and peripheral immunity in cerebral ischemia: partition and interaction.
CNS and peripheral immunity in cerebral ischemia: partition and interaction.
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DOI：
10.1016/j.expneurol.2020.113508
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发表时间：
2021-01
影响因子：
5.3
通讯作者：
Cho S
中科院分区：
文献类型：
--
作者：
Kim E;Cho S
中风会导致受损脑组织中的免疫系统过度激活。大脑中这种公认的神经炎症不仅是一种内在的器官反应，也是浸润性外周免疫细胞与受影响区域的常驻免疫细胞之间额外复杂相互作用的结果。考虑到在中风时生物体中存在有限数量的免疫细胞，CNS和外周的分区免疫系统必须在两个域之间适当地分配有限的免疫细胞池，通过向脑中供应足够数量的免疫细胞同时维持外周免疫来建立必要的中风后炎症反应。卒中的病理生理学主要以神经为中心，但了解中枢神经系统和外周免疫在对抗缺血性损伤的协同作用中的不同作用至关重要。这篇综述将讨论中风引起的外周免疫系统对中枢神经系统损伤/修复和神经炎症对外周免疫的影响，以及合并症如何影响每一个。
Stroke elicits excessive immune activation in the injured brain tissue. This well-recognized neural inflammation in the brain is not just an intrinsic organ response but also a result of additional intricate interactions between infiltrating peripheral immune cells and the resident immune cells in the affected areas. Given that there is a finite number of immune cells in the organism at the time of stroke, the partitioned immune systems of the CNS and periphery must appropriately distribute the limited pool of immune cells between the two domains, mounting a necessary post-stroke inflammatory response by supplying a sufficient number of immune cells into the brain while maintaining peripheral immunity. Stroke pathophysiology has mainly been neurocentric in focus, but understanding the distinct roles of the CNS and peripheral immunity in their concerted action against ischemic insults is crucial. This review will discuss stroke-induced influences of the peripheral immune system on CNS injury/repair and of neural inflammation on peripheral immunity, and how comorbidity influences each.
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影响因子：
3.7
作者：
Biagi E;Nylund L;Candela M;Ostan R;Bucci L;Pini E;Nikkïla J;Monti D;Satokari R;Franceschi C;Brigidi P;De Vos W
通讯作者：
De Vos W
影响因子：
82.9
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Benakis C;Brea D;Caballero S;Faraco G;Moore J;Murphy M;Sita G;Racchumi G;Ling L;Pamer EG;Iadecola C;Anrather J
通讯作者：
Anrather J
影响因子：
32.4
作者：
Angeli, V;Llodrá, J;Randolph, GJ
通讯作者：
Randolph, GJ
影响因子：
4.8
作者：
Ali, Awais;Shah, Fawad Ali;Li, Shupeng
通讯作者：
Li, Shupeng
影响因子：
4.2
作者：
Benyacoub, J;Czarnecki- Maulden, GL;von der Weid, T
通讯作者：
von der Weid, T