Whole-flock, metaphylactic tilmicosin failed to eliminate contagious ovine digital dermatitis and footrot in sheep: a cluster randomised trial.
Whole-flock, metaphylactic tilmicosin failed to eliminate contagious ovine digital dermatitis and footrot in sheep: a cluster randomised trial.
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DOI：
10.1136/vr.103625
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发表时间：
2016-09-24
期刊：
影响因子：
--
通讯作者：
Duncan JS
中科院分区：
文献类型：
--
作者：
Angell JW;Grove-White DH;Williams HJ;Duncan JS
本研究的目的是评价全群系统性替米考星在消除绵羊活动性传染性羊数字性皮炎（CODD）方面的临床成功和增强的生物安全性。在英国，30只羊被随机分配接受常规治疗（按照农场主的常规）或用替米考辛整群治疗，同时对临床感染个体进行隔离和延长治疗，并在研究期间对购买的羊进行隔离和治疗。在试验开始时对所有羊群进行一次访问，以检查所有羊。一年后，对所有羊进行重新检查，以确定是否存在临床病变。主要结局是禽群中CODD的临床消除。次要结果为CODD患病率降低、临床消除快步和快步患病率降低。分析包括11个对照羊群和13个干预羊群，最初分别有3460只羊和4686只羊。对于CODD：在随访中，干预组6/13（46%）鸡群的患病率为零，而对照组1/11（9%）鸡群的患病率为零（P=0.12）。对于小跑：在随访中，没有一个禽群的流行率为零。因此，在英国，不建议将干预措施用于消除CODD或步行。
The aim of this study was to evaluate the clinical success of whole-flock systemic tilmicosin and enhanced biosecurity in eliminating active contagious ovine digital dermatitis (CODD) from sheep flocks. Thirty flocks in the UK were randomly allocated to receive either treatment as usual (as per the farmer's normal routine) or whole-flock treatment with tilmicosin, together with isolation and extended treatment of clinically affected individuals and isolation and treatment of purchased sheep during the study period. All flocks were visited once at onset of the trial to examine all sheep. One year later, all sheep were re-examined to determine the presence/absence of clinical lesions. The primary outcome was the clinical elimination of CODD from flocks. Secondary outcomes were reduction in prevalence of CODD, clinical elimination of footrot and reduction in prevalence of footrot. The analysis included 11 control flocks and 13 intervention flocks, with initially 3460 and 4686 sheep, respectively. For CODD: at follow-up, in the intervention group, 6/13 (46 per cent) flocks had a prevalence of zero compared with 1/11 (9 per cent) in the control group (P=0.12). For footrot: at follow-up, no flocks had a prevalence of zero. Therefore, the intervention is not recommended for the elimination of CODD or footrot in the UK.
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影响因子：
2.2
作者：
Clements, R. H.;Stoye, S. C.
通讯作者：
Stoye, S. C.
影响因子：
2.2
作者：
Naccari, F;Giofrè, F;Carli, S
通讯作者：
Carli, S
影响因子：
2.2
作者：
Duncan, J. S.;Grove-White, D.;Williams, H. W.
通讯作者：
Williams, H. W.
影响因子：
0.8
作者：
EGERTON, JR;ROBERTS, DS
通讯作者：
ROBERTS, DS
影响因子：
2.2
作者：
Angell, J. W.;Cripps, P. J.;Duncan, J. S.
通讯作者：
Duncan, J. S.