Cooperativity between an Upstream TATA-like Sequence and a CAA Repeated Element Mediates E1A-dependent Negative Repression of the H-2K Class I Gene (*)
Cooperativity between an Upstream TATA-like Sequence and a CAA Repeated Element Mediates E1A-dependent Negative Repression of the H-2K Class I Gene (*)
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上游 TATA 样序列和 CAA 重复元件之间的协同作用介导 H-2K I 类基因的 E1A 依赖性负抑制 (*)
DOI：
10.1074/jbc.270.5.2327
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
K. Yokoyama
中科院分区：
文献类型：
--
作者：
Xiaoren Tang;Hai;O. Sakatsume;T. Ohta;H. Tsutsui;A. Smit;M. Horikoshi;P. Kourilsky;A. Israël;G. Gachelin;K. Yokoyama
In primary rodent cells transformed by the E1A region of the highly oncogenic adenovirus type 12, repression of transcription mediated by the far upstream TATA-like element was observed only in conjunction with either possible juxtaposition of a CAA repeated element in the presence of E1A and was dependent upon the relative arrangement of both the TATA-like and CAA repeated motifs in both homologous and heterologous promoter constructs. A gel shift competition study demonstrated that the TATA-binding protein (TBP) or a TBP-like protein can bind to both the upstream TATA-like sequence and the regular TATA box on the H-2K basal promoter. Moreover, employing immunoselection and cyclic amplification and selection of targets (CASTing) methods with nuclear extracts derived from Ad12-E1A transformants, we have identified a high affinity binding site in the H-2K class I promoter for E1A-associated DNA-binding proteins. The sequences of the binding sites were identified and were found to contain both the upstream TATA-like motif and the CAA repeated motifs. Our results suggest that the TATA-like sequence in the far upstream region of the H-2K gene is one of the elements that is required for Ad12-E1A-mediated negative repression.
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影响因子：
56.9
作者：
EDLUND, T;WALKER, MD;RUTTER, WJ
通讯作者：
RUTTER, WJ
腺病毒E1A蛋白与TATA盒结合转录因子IID之间的直接相互作用。
DOI：
10.1073/pnas.88.12.5124
发表时间：
1991
影响因子：
11.1
作者：
Horikoshi,N;Maguire,K;Kralli,A;Maldonado,E;Reinberg,D;Weinmann,R
通讯作者：
Weinmann,R
腺病毒 12 转化细胞中 MHC I 类增强子的 R2 元件的负调节与高水平的 COUP-TF 结合相关。
影响因子：
8
作者：
Liu,X;Ge,R;Westmoreland,S;Cooney,AJ;Tsai,SY;Tsai,MJ;Ricciardi,RP
通讯作者：
Ricciardi,RP
影响因子：
10.5
作者：
FAN, CM;MANIATIS, T
通讯作者：
MANIATIS, T
腺病毒 E1A 与 Holo-TFIID 的功能相互作用。
影响因子：
10.5
作者：
Boyer,TG;Berk,AJ
通讯作者：
Berk,AJ