High field parahydrogen induced polarization of succinate and phospholactate.
High field parahydrogen induced polarization of succinate and phospholactate.
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DOI：
10.1039/d0cp06281b
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发表时间：
2021-01-28
期刊：
影响因子：
--
通讯作者：
Hövener JB
中科院分区：
文献类型：
--
作者：
Berner S ;Schmidt AB ;Ellermann F ;Korchak S ;Chekmenev EY ;Glöggler S ;von Elverfeldt D ;Hennig J ;Hövener JB
代谢物核自旋超极化提供的信号增强是一种很有前途的磁共振成像诊断技术。迄今为止，大多数13c造影剂使用复杂的或成本高的偏振器进行超偏振。近年来，原位对氢诱导的13C超极化现象得到了证实。通过脉冲核磁共振序列实现氢化、自旋顺序转移（SOT）、体内给药和检测在7特斯拉核磁共振系统的磁孔内完成。到目前为止，外生分子1- 13c -羟乙基丙酸酯（HEP）和生物分子1- 13c -琥珀酸酯（SUC）分别通过PH-INEPT+序列和Goldman等人提出的SOT方案进行了超极化。在这里，我们进一步研究了7特斯拉下SUC的超极化，并研究了另外两个SOT序列的性能。此外，我们采用PH-INEPT+序列首次获得了1- 13c -磷酸乳酸酯（placc）在高磁场下的超极化结果，placc是一种衍生物，用于获得代谢物乳酸。对于SUC和placc， 13C极化约1 - 2%，在几秒钟内，用最少的设备。已经确定了可能解释13C极化损失的效应，即低氢化产率，快速T1/T2弛豫和很少考虑的13C同位素标记效应。
The signal enhancement provided by the hyperpolarization of nuclear spins of metabolites is a promising technique for diagnostic magnetic resonance imaging (MRI). To date, most 13C-contrast agents are hyperpolarized utilizing a complex or cost-intensive polarizer. Recently, the in situ parahydrogen-induced 13C hyperpolarization was demonstrated. Hydrogenation, spin order transfer (SOT) by a pulsed NMR sequence, in vivo administration, and detection was achieved within the magnet bore of a 7 Tesla MRI system. So far, the hyperpolarization of the xenobiotic molecule 1-13C-hydroxyethylpropionate (HEP) and the biomolecule 1-13C-succinate (SUC) through the PH-INEPT+ sequence and a SOT scheme proposed by Goldman et al., respectively, was shown. Here, we investigate further the hyperpolarization of SUC at 7 Tesla and study the performance of two additional SOT sequences. Moreover, we present first results of the hyperpolarization at high magnetic field of 1-13C-phospholactate (PLAC), a derivate to obtain the metabolite lactate, employing the PH-INEPT+ sequence. For SUC and PLAC, 13C polarizations of about 1–2 % were achieved within seconds and with minimal equipment. Effects that potentially may explain loss of 13C polarization have been identified, i.e. low hydrogenation yield, fast T1/T2 relaxation and the rarely considered 13C isotope labeling effect.
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影响因子：
2.2
作者：
Baer, Sebastien;Lange, Thomas;Hoevener, Jan-Bernd
通讯作者：
Hoevener, Jan-Bernd
影响因子：
7.4
作者：
de Graaf, Robin A.;Chowdhury, Golam M. I.;Behar, Kevin L.
通讯作者：
Behar, Kevin L.
DOI：
10.1007/s10334-013-0366-7
发表时间：
2013-10-01
影响因子：
2.3
作者：
Borowiak, Robert;Schwaderlapp, Niels;Hoevener, Jan-Bernd
通讯作者：
Hoevener, Jan-Bernd
影响因子：
2.3
作者：
Berner, Stephan;Schmidt, Andreas B.;Hoevener, Jan-Bernd
通讯作者：
Hoevener, Jan-Bernd
影响因子：
15
作者：
Haake, M;Natterer, J;Bargon, J
通讯作者：
Bargon, J