The association between long-term exposure to ambient fine particulate matter and glaucoma: A nation-wide epidemiological study among Chinese adults.
The association between long-term exposure to ambient fine particulate matter and glaucoma: A nation-wide epidemiological study among Chinese adults.
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长期暴露于环境细颗粒物与青光眼之间的关系：一项中国成年人的全国流行病学研究。
DOI：
10.1016/j.ijheh.2021.113858
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发表时间：
2021-09
影响因子：
6
通讯作者：
Yan, Hua
中科院分区：
文献类型：
--
作者：
Yang, Xueli;Yang, Ze;Liu, Yuanyuan;Chen, Xi;Yao, Baoqun;Liang, Fengchao;Shan, Anqi;Liu, Fangchao;Chen, Song;Yan, Xiaochang;Huang, Jianfeng;Bo, Shaoye;Liu, Yang;Tang, Naijun;Gu, Dongfeng;Yan, Hua
越来越多的证据证实了细颗粒物（PM2.5）与眼部疾病之间的联系，但长期暴露在PM2.5中对青光眼的影响却知之甚少。在中国10个省份开展了一项全国农村青光眼流行病学的横断面研究，纳入了33,701名40岁及以上的成年人。使用1公里分辨率的卫星模型来估计PM2.5浓度，该浓度根据地理编码的家庭住址分配给每个参与者。采用Logistic回归模型研究长期暴露于PM2.5与青光眼及其亚型之间的关系。估计PM2.5浓度在28.0至96.4 μg/m3之间。PM2.5每增加10 μg/m3，青光眼和原发性闭角型青光眼的校正优势比分别为1.07 （95% CI: 1.00-1.15）和1.14 （95% CI: 1.02-1.26）。长期暴露于PM2.5与原发性开角型青光眼发生率呈正相关（OR = 1.05, 95% CI: 0.92-1.18）。中年居民和非吸烟者对PM2.5的不良影响更为敏感。中国成人长期暴露于PM2.5与青光眼和PACG相关，为研究PM2.5对眼部的不良影响提供了新的思路。
A growing body of evidence has confirmed the association between fine particulate matter (PM2.5) and ocular diseases, but little is known on the effect of long-term PM2.5 exposure on glaucoma. A national cross-sectional study of the Rural Epidemiology for Glaucoma was conducted in 10 provinces of China, and 33,701 adults aged 40 years or more were included. A satellite-based model at 1-km resolution level was used to estimate PM2.5 concentrations which were assigned to each participant according to geocoded home addresses. Logistic regression model was performed to investigate associations of long-term PM2.5 exposure with glaucoma and its subtypes. Estimated PM2.5 concentrations ranged from 28.0 to 96.4 μg/m3. For each 10 μg/m3 increment in PM2.5, the adjusted odds ratios (ORs) were 1.07 (95% CI: 1.00–1.15) and 1.14 (95% CI: 1.02–1.26) for glaucoma and primary angle-closure glaucoma (PACG), respectively. A positive but non-significant association (OR = 1.05, 95% CI: 0.92–1.18) was detected between long-term exposure to PM2.5 and odds of primary open-angle glaucoma. The middle aged residents and non-smokers were more sensitive to the adverse effects of PM2.5. Long-term PM2.5 exposure was associated with glaucoma and PACG in Chinese adults, which provided new insights on adverse ophthalmic effect of PM2.5.
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DOI：
10.1016/s0140-6736(17)30505-6
发表时间：
2017-05-13
期刊：
Lancet (London, England)
影响因子：
--
作者：
Cohen AJ;Brauer M;Burnett R;Anderson HR;Frostad J;Estep K;Balakrishnan K;Brunekreef B;Dandona L;Dandona R;Feigin V;Freedman G;Hubbell B;Jobling A;Kan H;Knibbs L;Liu Y;Martin R;Morawska L;Pope CA 3rd;Shin H;Straif K;Shaddick G;Thomas M;van Dingenen R;van Donkelaar A;Vos T;Murray CJL;Forouzanfar MH
通讯作者：
Forouzanfar MH
影响因子：
4.1
作者：
Chua, Sharon Y. L.;Warwick, Alasdair;Patel, Praveen J.
通讯作者：
Patel, Praveen J.
影响因子：
15.1
作者：
Maddineni, Prabhavathi;Kasetti, Ramesh B.;Zode, Gulab S.
通讯作者：
Zode, Gulab S.
影响因子：
9.8
作者：
Mimura, Tatsuya;Ichinose, Takamichi;Matsubara, Masao
通讯作者：
Matsubara, Masao
影响因子：
24.3
作者：
Liu, Shuo;Jorgensen, Jeanette Therming;Andersen, Zorana Jovanovic
通讯作者：
Andersen, Zorana Jovanovic