Understanding the adsorption interface of polyelectrolyte coating on redox active nanoparticles using soft particle electrokinetics and its biological activity.
Understanding the adsorption interface of polyelectrolyte coating on redox active nanoparticles using soft particle electrokinetics and its biological activity.
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DOI：
10.1021/am405250g
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发表时间：
2014-04-23
影响因子：
9.5
通讯作者：
Seal, Sudipta
中科院分区：
文献类型：
--
作者：
Saraf, Shashank;Neal, Craig J.;Das, Soumen;Barkam, Swetha;McCormack, Rameech;Seal, Sudipta
关键词：
用于治疗目的的氧化铈纳米颗粒(CNPs)的应用需要纳米颗粒在生物环境中的稳定分散。本研究的目的是通过改变聚合物包覆碳纳米颗粒的相对分子质量来获得稳定的催化活性分散体。用聚丙烯酸(PAA)包覆碳纳米管，提高了碳纳米管的分散稳定性，增强了催化性能。用Langmuir吸附模型计算的Gibbs自由能变化来分析PAA涂层的稳定性。吸附等温线用软颗粒电动力学测定，克服了其他技术带来的挑战。当PAA的包覆量为250 kg/mol时，碳纳米管的Gibbs自由能变化最大，说明包覆层最稳定。100 kg/mol包覆碳纳米管的PAA自由能变化比250 kg/mol包覆碳纳米管的PAA低85%。这一显著差异是由于CNPS对100 kg/mol的PAA的强吸附所致。通过纳米颗粒的过氧化氢酶模拟活性来评价PAA-CNPS的催化活性。PAA包覆碳纳米管的过氧化氢酶活性高于裸碳纳米管，这表明包覆碳纳米管优先吸附过氧化氢。这表明过氧化氢酶的活性也受涂层结构的影响。
The application of cerium oxide nanoparticles (CNPs) for therapeutic purposes requires a stable dispersion of nanoparticles in a biological environment. The objective of this study is to tailor the properties of polyelectrolyte coated CNPs as a function of molecular weight to achieve a stable and catalytic active dispersion. The coating of CNPs with polyacrylic acid (PAA) has increased the dispersion stability of CNPs and enhanced the catalytic ability. The stability of PAA coating was analyzed using the change in the Gibbs free energy computed by the Langmuir adsorption model. The adsorption isotherms were determined using soft particle electrokinetics which overcomes the challenges presented by other techniques. The change in Gibbs free energy was highest for CNPs coated with PAA of 250 kg/mol indicating the most stable coating. The change in free energy for PAA of 100 kg/mol coated CNPs was 85% lower than the PAA of 250 kg/mol coated CNPs. This significant difference is caused by the strong adsorption of PAA of 100 kg/mol on CNPs. Catalytic activity of PAA-CNPs is assessed by the catalase enzymatic mimetic activity of nanoparticles. The catalase activity was higher for PAA coated CNPs as compared to bare CNPs which indicated preferential adsorption of hydrogen peroxide induced by coating. This indicates that the catalase activity is also affected by the structure of the coating layer.
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影响因子：
14
作者：
Das S;Singh S;Dowding JM;Oommen S;Kumar A;Sayle TX;Saraf S;Patra CR;Vlahakis NE;Sayle DC;Self WT;Seal S
通讯作者：
Seal S
影响因子：
3.7
作者：
Fresnais, J.;Lavelle, C.;Berret, J. -F.
通讯作者：
Berret, J. -F.
纳米症：一种稀土纳米颗粒，是一种新型的卵巢癌抗血管生成治疗剂。
影响因子：
3.7
作者：
Giri S;Karakoti A;Graham RP;Maguire JL;Reilly CM;Seal S;Rattan R;Shridhar V
通讯作者：
Shridhar V
影响因子：
15
作者：
Karakoti, Ajay S.;Singh, Sanjay;Kumar, Amit;Malinska, Maura;Kuchibhatla, Satyanarayana V. N. T.;Wozniak, Krzysztof;Self, William T.;Seal, Sudipta
通讯作者：
Seal, Sudipta
DOI：
10.1016/j.jeurceramsoc.2006.05.109
发表时间：
2007-01-01
影响因子：
5.7
作者：
Karimian, H.;Babaluo, A. A.
通讯作者：
Babaluo, A. A.