Beyond cardiomyocytes: Cellular diversity in the heart's response to exercise.
Beyond cardiomyocytes: Cellular diversity in the heart's response to exercise.
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DOI：
10.1016/j.jshs.2022.12.011
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发表时间：
2023-07
影响因子：
11.7
通讯作者：
Rosenzweig A
中科院分区：
文献类型：
--
作者：
Trager LE;Lyons M;Kuznetsov A;Sheffield C;Roh K;Freeman R;Rhee J;Guseh JS;Li H;Rosenzweig A
多种细胞系有助于运动对心脏的影响。非心肌细胞之间以及非心肌细胞与心肌细胞之间的交互作用是心脏运动反应的必要条件。心肌细胞占成年哺乳动物心脏总体积的70%至85%，但仅占其细胞总数的约25%至35%。单细胞和单核RNA测序的进展极大地促进了对心脏中非心肌细胞的潜在功能的研究和提高了对这些功能的认识。虽然大部分工作都集中在非心肌细胞，疾病和心脏对病理应激反应之间的关系上，但了解这些细胞在健康心脏，心脏稳态和对生理应激反应（如运动）中的作用也很重要。本文综述了近年来非心肌细胞对运动生理应激反应的动态变化。特别感兴趣的是纤维化途径、心脏血管系统和免疫或炎症细胞的变化。在许多情况下，关于特定谱系如何响应运动而变化或观察到的变化是否具有功能重要性的数据有限，这强调了进一步研究的必要性。
Multiple cell linages contribute to the effects of exercise on the heart. Cross-talk among non-cardiomyocytes and non-cardiomyocytes to cardiomyocytes are necessary in cardiac response to exercise. Cardiomyocytes comprise ∼70% to 85% of the total volume of the adult mammalian heart but only about 25% to 35% of its total number of cells. Advances in single cell and single nuclei RNA sequencing have greatly facilitated investigation into and increased appreciation of the potential functions of non-cardiomyocytes in the heart. While much of this work has focused on the relationship between non-cardiomyocytes, disease, and the heart's response to pathological stress, it will also be important to understand the roles that these cells play in the healthy heart, cardiac homeostasis, and the response to physiological stress such as exercise. The present review summarizes recent research highlighting dynamic changes in non-cardiomyocytes in response to the physiological stress of exercise. Of particular interest are changes in fibrotic pathways, the cardiac vasculature, and immune or inflammatory cells. In many instances, limited data are available about how specific lineages change in response to exercise or whether the changes observed are functionally important, underscoring the need for further research.
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影响因子：
20.1
作者：
Calvert JW;Condit ME;Aragón JP;Nicholson CK;Moody BF;Hood RL;Sindler AL;Gundewar S;Seals DR;Barouch LA;Lefer DJ
通讯作者：
Lefer DJ
影响因子：
5
作者：
Bowers SL;Banerjee I;Baudino TA
通讯作者：
Baudino TA
影响因子：
8
作者：
Adamo, Luigi;Rocha-Resende, Cibele;Mann, Douglas L.
通讯作者：
Mann, Douglas L.
影响因子：
64.5
作者：
Bersell, Kevin;Arab, Shima;Kuehn, Bernhard
通讯作者：
Kuehn, Bernhard
DOI：
10.1073/pnas.0603615103
发表时间：
2006-06-27
影响因子：
11.1
作者：
Arany, Zoltan;Novikov, Mikhail;Spiegelman, Bruce M.
通讯作者：
Spiegelman, Bruce M.