Molecular characterization of rabbit renal epithelial calcium channel.
Molecular characterization of rabbit renal epithelial calcium channel.
复制标题
兔肾上皮钙通道的分子特征。
DOI:
10.1006/bbrc.2000.4136
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发表时间:
2001
期刊:
影响因子:
--
通讯作者:
O'Neil,RG
中科院分区:
文献类型:
--
作者:
Zhang,MI;O'Neil,RG
PCR and antisense oligodeoxy-neucleotide (ODN) blocking were used to identify a calcium (Ca) channel in rabbit proximal tubule (PT) cells. The subcloned Ca channel is identical to the rabbit cardiac Ca channel (α1) except a 33 base deletion at the fourth S3-S4 linker in PT cells. Anti-sense ODN treatment (18 h) inhibited 73 and 44% of Ca influxes induced by hypoosmotic stress (220 Osm) and by 1-oleoyl-2-acetyl-sn-glycerol (5 μM), respectively. The results indicate that the subcloned channel is a spliced variant of the cardiac Ca channel and that it plays a critical role in regulation of Ca signaling in these cells.
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DOI:
--
发表时间:
1997
期刊:
Biochemical and Biophysical Research Communications - BBRC
影响因子:
--
作者:
R. O'neil;J. M. Reid;R. Williams;N. Karin
通讯作者:
N. Karin
DOI:
10.1073/pnas.90.9.3787
发表时间:
1993-05-01
影响因子:
11.1
作者:
HORNE, WA;ELLINOR, PT;SCHWARZ, TL
通讯作者:
SCHWARZ, TL
DOI:
10.1096/fasebj.11.11.9285484
发表时间:
1997
期刊:
The FASEB Journal
影响因子:
--
作者:
O. Strauß;S. Mergler;Michael Wbederholt
通讯作者:
Michael Wbederholt
DOI:
--
发表时间:
--
期刊:
影响因子:
--
作者:
通讯作者:
--
影响因子:
4.4
作者:
Ueda,Y;Steinberg,RH
通讯作者:
Steinberg,RH