Identifying cost-effective dynamic policies to control epidemics.

Identifying cost-effective dynamic policies to control epidemics.
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DOI:
10.1002/sim.7047
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发表时间:
2016-12-10
影响因子:
2
通讯作者:
Cohen, Ted
Cohen, Ted
中科院分区:
医学3区
文献类型:
--
作者:
Yaesoubi, Reza;Cohen, Ted

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我们描述了一个数学决策模型,用于确定控制流行病的动态卫生政策。这些动态政策旨在根据累积的流行病数据和每个决策点的资源可用性选择最佳的当前干预措施。我们提出了一个算法来近似动态政策,优化人口的净健康效益,一个性能指标,占健康和货币的结果。我们进一步说明了如何定义和优化动态政策,以控制一种新的病毒病原体,其中政策制定者必须决定(i)何时采用或解除减少传播的干预措施(例如学校关闭),以及(ii)当有限数量的疫苗首次上市时,如何优先考虑人口成员进行疫苗接种。在此应用程序的背景下,我们证明了动态的政策可以产生更高的净健康效益比更常见的静态政策,指定一个预先确定的干预序列,在整个流行病。
We describe a mathematical decision model for identifying dynamic health policies for controlling epidemics. These dynamic policies aim to select the best current intervention based on accumulating epidemic data and the availability of resources at each decision point. We propose an algorithm to approximate dynamic policies that optimize the population’s net health benefit, a performance measure which accounts for both health and monetary outcomes. We further illustrate how dynamic policies can be defined and optimized for the control of a novel viral pathogen, where a policy maker must decide (i) when to employ or lift a transmission-reducing intervention (e.g. school closure) and (ii) how to prioritize population members for vaccination when a limited quantity of vaccines first become available. Within the context of this application, we demonstrate that dynamic policies can produce higher net health benefit than more commonly described static policies that specify a pre-determined sequence of interventions to employ throughout epidemics.
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