Differential Association of Serum n-3 Polyunsaturated Fatty Acids with Various Cerebrovascular Lesions in Japanese Men
Differential Association of Serum n-3 Polyunsaturated Fatty Acids with Various Cerebrovascular Lesions in Japanese Men
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日本男性血清 n-3 多不饱和脂肪酸与各种脑血管病变的差异关联
DOI：
10.1159/000524243
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发表时间：
2022
影响因子：
2.9
通讯作者：
for th
中科院分区：
文献类型：
--
作者：
Kondo Keiko;Arima Hisatomi;Fujiyoshi Akira;Sekikawa Akira;Kadota Aya;Hisamatsu Takashi;Torii Sayuki;Shiino Akihiko;Morino Katsutaro;Miyagawa Naoko;Segawa Hiroyoshi;Watanabe Yoshiyuki;Maegawa Hiroshi;Nozaki Kazuhiko;Miura Katsuyuki;Ueshima Hirotsugu;for th
背景：大量摄入海洋来源的n-3多不饱和脂肪酸（n-3 PUFAs）与较低的冠心病风险之间存在关联，此前已有报道。然而，n-3 PUFAs与脑血管病变之间的关系尚不清楚。我们在以日本男性为基础的普通人群样本中评估了这种关联。方法研究对象为居住在日本滋贺草津市的男性，年龄40-79岁。2006年至2008年，采用气液色谱法测定了血清n-3 PUFAs浓度（定义为二十碳五烯酸和二十二碳六烯酸的总和）。2012 - 2015年采用磁共振成像评估脑血管病变（包括脑内大动脉狭窄、腔隙性梗死、微出血）和白质病变。对常规心血管危险因素进行Logistic回归校正，估计血清n-3 PUFAs浓度每1个标准差较高的脑血管病变的优势比。结果739例男性中，脑大动脉狭窄、腔隙性梗死、微出血和白质病变的发生率分别为222例（30.0）、162例（21.9）、103例（13.9）和164例（22.2）。n-3 PUFAs浓度升高1个标准差（30.5 μmol/L）与脑大动脉狭窄发生率降低独立相关（多变量校正优势比0.80；95%可信区间0.67-0.97）。n-3 PUFAs与其他类型病变无显著相关性。结论sn-3 PUFAs对脑内大动脉狭窄有保护作用，但对小血管病变无保护作用。
BackgroundAn association between a high intake of marine-derived n-3 polyunsaturated fatty acids (n-3 PUFAs) with a lower risk of coronary heart disease was previously reported. However, the association between n-3 PUFAs and cerebrovascular lesions remains unclear. We evaluated this association in a general-population-based sample of Japanese men.MethodsParticipants were community-dwelling men (40–79 years old) living in Kusatsu City, Shiga, Japan. Serum concentrations of n-3 PUFAs, defined as the sum of eicosapentaenoic and docosahexaenoic acids, were measured via gas-liquid chromatography between 2006 and 2008. Magnetic resonance imaging was used to assess cerebrovascular lesions (including intracerebral large-artery stenosis, lacunar infarction, and microbleeds) and white matter lesions between 2012 and 2015. Logistic regression adjusting for conventional cardiovascular risk factors was used to estimate the odds ratio of prevalent cerebrovascular lesions per 1 standard deviation higher serum concentration of n-3 PUFAs.ResultsOf a total of 739 men, the numbers (crude prevalence in%) of prevalent cerebral large-artery stenoses, lacunar infarctions, microbleeds, and white matter lesions were 222 (30.0), 162 (21.9), 103 (13.9), and 164 (22.2), respectively. A 1 standard deviation higher concentration of n-3 PUFAs (30.5 μmol/L) was independently associated with lower odds of cerebral large-artery stenosis (multivariable-adjusted odds ratio, 0.80; 95% confidential interval, 0.67–0.97). There were no significant associations of n-3 PUFAs with the other types of lesions.Conclusionsn-3 PUFAs may have protective effects against large-artery stenosis, but not small vessel lesions, in the brain.
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影响因子：
8.3
作者：
Iso, H;Sato, S;Shimamoto, T
通讯作者：
Shimamoto, T
影响因子：
3.4
作者：
Matsui R;Nakagawa T;Takayoshi H;Onoda K;Oguro H;Nagai A;Yamaguchi S
通讯作者：
Yamaguchi S
影响因子：
3.3
作者：
Ohira, Tetsuya;Iso, Hiroyasu
通讯作者：
Iso, Hiroyasu
牛奶、肉类和鱼类对日本脑血管疾病死亡率的可能保护作用。
影响因子：
4.7
作者：
Y. Kinjo;V. Beral;Suminori Akiba;T. Key;Shoichi Mizuno;Paul N. Appleby;Naohito Yamaguchi;Shaw Watanabe;R. Doll
通讯作者：
R. Doll
影响因子：
4.9
作者：
Arima, Hisatomi;Anderson, Craig;Chalmers, John
通讯作者：
Chalmers, John