The reactome pathway knowledgebase 2022.
The reactome pathway knowledgebase 2022.
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DOI：
10.1093/nar/gkab1028
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发表时间：
2022-01-07
影响因子：
14.9
通讯作者：
D'Eustachio P
中科院分区：
文献类型：
--
作者：
Gillespie M;Jassal B;Stephan R;Milacic M;Rothfels K;Senff-Ribeiro A;Griss J;Sevilla C;Matthews L;Gong C;Deng C;Varusai T;Ragueneau E;Haider Y;May B;Shamovsky V;Weiser J;Brunson T;Sanati N;Beckman L;Shao X;Fabregat A;Sidiropoulos K;Murillo J;Viteri G;Cook J;Shorser S;Bader G;Demir E;Sander C;Haw R;Wu G;Stein L;Hermjakob H;D'Eustachio P
Reactome知识基础（https://reactome.org）是一种长生不老的核心资源，在人类的各种物理和病理生物学过程中提供了手动策划的分子细节，包括遗传性和获得性疾病过程。因此，单个一致的数据模型中的分子转换网络既是手动策划的人类生物学过程的数字存档，又是发现数据中的功能关系的工具，例如来自肿瘤细胞的基因表达谱或体细胞突变策展工作扩大了我们对正常和疾病相关的信号传导过程的注释，以及针对它们的药物，特别是由SARS-COV-1和SARS-COV-2冠状病毒引起的感染以及宿主对感染的反应在Reactome手动策划的途径的背景下，对来自多个来源的高通量数据的更简单分析以及分析数据集的理解（“黑暗”）蛋白的放置。
The Reactome Knowledgebase (https://reactome.org), an Elixir core resource, provides manually curated molecular details across a broad range of physiological and pathological biological processes in humans, including both hereditary and acquired disease processes. The processes are annotated as an ordered network of molecular transformations in a single consistent data model. Reactome thus functions both as a digital archive of manually curated human biological processes and as a tool for discovering functional relationships in data such as gene expression profiles or somatic mutation catalogs from tumor cells. Recent curation work has expanded our annotations of normal and disease-associated signaling processes and of the drugs that target them, in particular infections caused by the SARS-CoV-1 and SARS-CoV-2 coronaviruses and the host response to infection. New tools support better simultaneous analysis of high-throughput data from multiple sources and the placement of understudied (‘dark’) proteins from analyzed datasets in the context of Reactome’s manually curated pathways.
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影响因子：
14.9
作者：
Kanehisa M;Furumichi M;Sato Y;Ishiguro-Watanabe M;Tanabe M
通讯作者：
Tanabe M
影响因子：
14.9
作者：
Lombardot T;Morgat A;Axelsen KB;Aimo L;Hyka-Nouspikel N;Niknejad A;Ignatchenko A;Xenarios I;Coudert E;Redaschi N;Bridge A
通讯作者：
Bridge A
影响因子：
14.9
作者：
Papatheodorou, Irene;Moreno, Pablo;Brazma, Alvis
通讯作者：
Brazma, Alvis
影响因子：
--
作者：
Draper-Joyce, Christopher;Furness, Sebastian George Barton
通讯作者：
Furness, Sebastian George Barton
DOI：
10.1038/nrd.2018.14
发表时间：
2018-05
期刊：
Nature reviews. Drug discovery
影响因子：
--
作者：
Oprea TI;Bologa CG;Brunak S;Campbell A;Gan GN;Gaulton A;Gomez SM;Guha R;Hersey A;Holmes J;Jadhav A;Jensen LJ;Johnson GL;Karlson A;Leach AR;Ma'ayan A;Malovannaya A;Mani S;Mathias SL;McManus MT;Meehan TF;von Mering C;Muthas D;Nguyen DT;Overington JP;Papadatos G;Qin J;Reich C;Roth BL;Schürer SC;Simeonov A;Sklar LA;Southall N;Tomita S;Tudose I;Ursu O;Vidovic D;Waller A;Westergaard D;Yang JJ;Zahoránszky-Köhalmi G
通讯作者：
Zahoránszky-Köhalmi G