"Living like an empty gas tank with a leak": Mixed methods study on post-acute sequelae of COVID-19.
"Living like an empty gas tank with a leak": Mixed methods study on post-acute sequelae of COVID-19.
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DOI：
10.1371/journal.pone.0279684
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
Commodore-Mensah, Yvonne
中科院分区：
文献类型：
--
作者：
Ogungbe, Oluwabunmi;Slone, Sarah;Alharthi, Abeer;Tomiwa, Tosin;Kumbe, Baridosia;Bergman, Alanna;McNabb, Katherine;Wright, Rhonda Smith;Farley, Jason E.;Himmelfarb, Cheryl R. Dennison;Cooper, Lisa A.;Post, Wendy S.;Davidson, Patricia M.;Commodore-Mensah, Yvonne
SARS-CoV-2感染后急性后遗症（PASC）的负担和表现是一个发展中的主要公共卫生问题。描述PASC在社区居民中的负担，并了解PASC患者的生活经历。这项针对COVID-19阳性社区居民的混合方法研究涉及调查和深入访谈。主要结局是COVID-19检测阳性后3周或更长时间自我报告可能的PASC症状。深度访谈以半结构化访谈指南为指导，其中包括开放式问题和基于PASC和COVID-19影响的新兴文献的探索。调查响应率为70%，442名参与者被纳入该分析，平均（SD）年龄为45.4（16.2）岁，71%为女性，12%为黑人/非裔美国人。与没有PASC症状的人相比，报告PASC症状的人更可能是老年人（平均年龄：46.5 vs. 42; p = 0.013），女性（74.3% vs. 61.2%; p = 0.010），有既存疾病（49.6% vs. 34%; p = 0.005），以及因COVID-19住院（14.2% vs. 2.9%; p = 0.002）。大约30%的参与者经历了严重的疲劳;在有PASC症状的人群中，报告严重疲劳的比例高出7倍（校正的患病率比[aPR] 6.73，95%CI：2.80-16.18）。有PASC症状的人更可能报告生活质量差（16% vs. 5%，p<0.001）和心理健康功能差（平均差异：-1.87 95%CI：-2.38，-1.37，p<0.001）。深入访谈的主题显示，PASC的经历是令人衰弱的。在这项研究中，PASC在社区居住的成年人中的患病率很高。参与者报告了相当大的应对困难，日常活动的限制，症状和经验的不可见性，以及获得和接受PASC护理的障碍。
The burden and presentation of post-acute sequela of SARS-CoV-2 infection (PASC) are a developing major public health concern. To characterize the burden of PASC in community-dwelling individuals and understand the experiences of people living with PASC. This mixed-methods study of COVID-19 positive community-dwelling persons involved surveys and in-depth interviews. Main outcome was self-report of possible PASC symptoms 3 weeks or longer after positive COVID-19 test. In-depth interviews were guided by a semi-structured interview guide with open-ended questions and probes based on emerging literature on PASC and the impact of COVID-19. With a survey response rate of 70%, 442 participants were included in this analysis, mean (SD) age 45.4 (16.2) years, 71% female, 12% Black/African American. Compared to those with no PASC symptoms, persons who reported PASC symptoms were more likely to be older (mean age: 46.5 vs. 42; p = 0.013), female (74.3% vs. 61.2%; p = 0.010), to have pre-existing conditions (49.6% vs. 34%; p = 0.005), and to have been hospitalized for COVID-19 (14.2% vs. 2.9%; p = 0.002). About 30% of the participants experienced severe fatigue; the proportion of persons reporting severe fatigue was 7-fold greater in those with PASC symptoms (Adjusted Prevalence Ratio [aPR] 6.73, 95%CI: 2.80–16.18). Persons with PASC symptoms were more likely to report poor quality of life (16% vs. 5%, p<0.001) and worse mental health functioning (Mean difference: -1.87 95%CI: -2.38, -1.37, p<0.001). Themes from in-depth interviews revealed PASC was experienced as debilitating. In this study, the prevalence of PASC among community-dwelling adults was substantial. Participants reported considerable coping difficulties, restrictions in everyday activities, invisibility of symptoms and experiences, and impediments to getting and receiving PASC care.
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影响因子：
4.7
作者：
Kiger, Michelle E.;Varpio, Lara
通讯作者：
Varpio, Lara
COVID-19 的 50 多种长期影响：系统回顾和荟萃分析。
影响因子：
4.6
作者：
Lopez-Leon S;Wegman-Ostrosky T;Perelman C;Sepulveda R;Rebolledo PA;Cuapio A;Villapol S
通讯作者：
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成人共卷199岁和≥65岁的成人共同条件 - 2020年3月至2021年11月，美国
DOI：
10.15585/mmwr.mm7121e1
发表时间：
2022-05-27
期刊：
Morbidity and Mortality Weekly Report
影响因子：
--
作者：
通讯作者：
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影响因子：
2.3
作者：
Mohr A;Dannerbeck L;Lange TJ;Pfeifer M;Blaas S;Salzberger B;Hitzenbichler F;Koch M
通讯作者：
Koch M
影响因子：
3.7
作者：
Matsushita K;Ding N;Kou M;Hu X;Chen M;Gao Y;Honda Y;Zhao D;Dowdy D;Mok Y;Ishigami J;Appel LJ
通讯作者：
Appel LJ