Experimental occlusal interference on brain activation during gum chewing
Experimental occlusal interference on brain activation during gum chewing
复制标题
咀嚼口香糖期间大脑激活的实验性咬合干扰
作者：
T. Otsuka;K. Sasaguri;Y. Hayashi;Kentaro Yamada;Hiroyuki Muranaka;Yumiko Takakura;Hitoshi Usuniwa;N. Doi;T. Kawata
本研究的目的是通过分析咬合干扰对大脑激活部位的影响以及感觉评估的结果来研究大脑功能。在11名受试者中，为左下颌第一磨牙制作干扰冠，受试者在有冠覆盖（200 μm咬合干扰）和无冠覆盖（对照）的情况下进行咀嚼口香糖任务。使用视觉模拟量表（VAS）评价感觉，使用功能性磁共振成像（fMRI）评价脑激活部位。结果被认为在p<0.05时具有统计学显著性。咀嚼口香糖时的不适感干预组显著高于对照组（p<0.01）。在fMRI分组分析中，两组均激活了躯体感觉-运动皮层、辅助运动区、小脑和小脑，从而建立了分析咬合干扰与脑功能关系的实验模型。在干预组中，杏仁核（p<0.001）、前扣带皮层（p <0.001）、前额区（p<0.05）和下丘脑（p<0.05）的激活程度显著较高。我们的研究结果表明，咬合干扰的刺激会迅速传递到大脑，并与不适情绪的激活有关。
This study aimed to investigate brain functions by analysing changes in intensity of brain activation sites as well as the results of sensory evaluation related to occlusal interference. In 11 subjects, an interference crown was made for the left mandibular first molar, and subjects performed a gum-chewing task with crown overlay (200 μm of occlusal interference) and without (control). Sensation was evaluated using a Visual Analog Scale (VAS), and brain activation sites were evaluated using functional Magnetic Resonance Imaging (fMRI). Results were considered statistically significant at p<0.05. Unpleasant sensation during gum chewing was significantly greater in the interference group than the control group (p<0.01). On fMRI group analysis, the somatosensory-motor cortex, supplementary motor area, the insula, and the cerebellum were activated in both groups, thus establishing an experimental model to analyse the relationship between occlusal interference and brain function. In the interference group, activation was significantly higher in the amygdala (p<0.001), anterior cingulate cortex (p<0.001), prefrontal area (p<0.05), and hypothalamus (p<0.05). Our findings show that stimulation from occlusal interference is rapidly relayed to the brain and related to activation of emotions of discomfort.
影响因子：
7.6
作者：
Onozuka, M;Fujita, M;Saito, S
通讯作者：
Saito, S
DOI：
10.1179/crn.2009.014
发表时间：
2009-04-01
影响因子：
1.6
作者：
Otsuka, Takero;Watanabe, Kazuko;Sasaguri, Kenichi
通讯作者：
Sasaguri, Kenichi