Mixed Candida albicans strain populations in colonized and infected mucosal tissues.

Mixed Candida albicans strain populations in colonized and infected mucosal tissues.
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DOI:
10.1111/j.1567-1364.2008.00438.x
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发表时间:
2008-12
影响因子:
3.2
通讯作者:
Odds FC
Odds FC
中科院分区:
生物学4区
文献类型:
--
作者:
Jacobsen MD;Duncan AD;Bain J;Johnson EM;Naglik JR;Shaw DJ;Gow NA;Odds FC

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对6个白色念珠菌的初步分离平板进行多位点序列分型,发现单个口咽和阴道标本中存在菌落间微变异和携带两种菌株类型。共生样本中较高的菌落变异率表明,在向致病性转变或对抗真菌治疗的反应中,从混合种群中选择了类型。
Multilocus sequence typing of six Candida albicans colonies from primary isolation plates revealed instances of colony-to-colony microvariation and carriage of two strain types in single oropharyngeal and vaginal samples. Higher rates of colony variation in commensal samples suggest selection of types from mixed populations either in the shift to pathogenicity or the response to antifungal treatment.
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