Reward value comparison via mutual inhibition in ventromedial prefrontal cortex.
Reward value comparison via mutual inhibition in ventromedial prefrontal cortex.
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DOI：
10.1016/j.neuron.2014.04.032
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发表时间：
2014-06-18
期刊：
影响因子：
16.2
通讯作者：
Hayden BY
中科院分区：
文献类型：
--
作者：
Strait CE;Blanchard TC;Hayden BY
Recent theories suggest that reward-based choice reflects competition between value signals in the ventromedial prefrontal cortex (vmPFC). We tested this idea by recording vmPFC neurons while macaques performed a gambling task with asynchronous offer presentation. We found that neuronal activity shows four patterns consistent with selection via mutual inhibition. (1) Correlated tuning for probability and reward size, suggesting that vmPFC carries an integrated value signal, (2) anti-correlated tuning curves for the two options, suggesting mutual inhibition, (3) neurons rapidly come to signal the value of the chosen offer, suggesting the circuit serves to produce a choice, (4) after regressing out the effects of option values, firing rates still could predict choice – a choice probability signal. In addition, neurons signaled gamble outcomes, suggesting that vmPFC contributes to both monitoring and choice processes. These data suggest a possible mechanism for reward-based choice and endorse the centrality of vmPFC in that process.
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DOI：
10.1126/science.1168488
发表时间：
2009-05-15
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hayden BY;Pearson JM;Platt ML
通讯作者：
Platt ML
影响因子：
4.3
作者：
Heilbronner SR;Hayden BY;Platt ML
通讯作者：
Platt ML
影响因子：
4.3
作者：
Hunt LT;Woolrich MW;Rushworth MF;Behrens TE
通讯作者：
Behrens TE
影响因子：
5.3
作者：
Genovesio, Aldo;Tsujimoto, Satoshi;Wise, Steven P.
通讯作者：
Wise, Steven P.
影响因子：
16.2
作者：
Boorman, Erie D.;Behrens, Timothy E. J.;Rushworth, Matthew F. S.
通讯作者：
Rushworth, Matthew F. S.