Mitochondria: Insights into Crucial Features to Overcome Cancer Chemoresistance.
Mitochondria: Insights into Crucial Features to Overcome Cancer Chemoresistance.
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线粒体：克服癌症化疗耐药的关键特征。
DOI：
10.3390/ijms22094770
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发表时间：
2021-04-30
影响因子：
5.6
通讯作者：
Giorgi C
中科院分区：
文献类型：
--
作者：
Genovese I;Carinci M;Modesti L;Aguiari G;Pinton P;Giorgi C
线粒体是细胞存活的关键调节因子，参与多种机制，如代谢、钙信号、活性氧(ROS)的产生、有丝分裂和线粒体的转移、融合和分裂(称为线粒体动力学)。这些过程在病理生理条件下的调节是细胞死亡和存活之间平衡的基础。的确，ROS过量生产和线粒体钙超载与诱导细胞凋亡有关，而线粒体动力学和新陈代谢的损伤在细胞生存和死亡的决定中可以起到双重作用。肿瘤发生涉及一系列错综复杂的尚未完全阐明的细胞损伤，而癌细胞中凋亡抵抗机制的启动又增加了更高水平的复杂性。在大多数情况下，癌症复发或缺乏反应性与化疗耐药的出现有关，这可能是由于几种细胞保护机制的合作，通常与线粒体有关。在这篇综述中，我们将重点报道线粒体动力学、线粒体钙信号、氧化应激和新陈代谢等与肿瘤化疗耐药相关的现有证据，以期找到克服癌症耐药的新途径或靶点。
Mitochondria are key regulators of cell survival and are involved in a plethora of mechanisms, such as metabolism, Ca2+ signaling, reactive oxygen species (ROS) production, mitophagy and mitochondrial transfer, fusion, and fission (known as mitochondrial dynamics). The tuning of these processes in pathophysiological conditions is fundamental to the balance between cell death and survival. Indeed, ROS overproduction and mitochondrial Ca2+ overload are linked to the induction of apoptosis, while the impairment of mitochondrial dynamics and metabolism can have a double-faceted role in the decision between cell survival and death. Tumorigenesis involves an intricate series of cellular impairments not yet completely clarified, and a further level of complexity is added by the onset of apoptosis resistance mechanisms in cancer cells. In the majority of cases, cancer relapse or lack of responsiveness is related to the emergence of chemoresistance, which may be due to the cooperation of several cellular protection mechanisms, often mitochondria-related. With this review, we aim to critically report the current evidence on the relationship between mitochondria and cancer chemoresistance with a particular focus on the involvement of mitochondrial dynamics, mitochondrial Ca2+ signaling, oxidative stress, and metabolism to possibly identify new approaches or targets for overcoming cancer resistance.
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影响因子：
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作者：
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