Type 2 Cystatins and Their Roles in the Regulation of Human Immune Response and Cancer Progression.
Type 2 Cystatins and Their Roles in the Regulation of Human Immune Response and Cancer Progression.
复制标题
DOI：
10.3390/cancers15225363
复制
发表时间：
2023-11-10
期刊：
影响因子：
5.2
通讯作者：
Zhan, Fenghuang
中科院分区：
文献类型：
--
作者：
Zhang, Zijun;Zhan, Fenghuang
2型半胱氨酸蛋白酶抑制剂是一组调节半胱氨酸蛋白酶组织蛋白酶和豆荚蛋白酶的小分泌蛋白酶抑制剂。这些酶调节与免疫反应和肿瘤进展相关的重要细胞过程，在自身免疫性疾病和各种类型的癌症中发挥重要作用。本文综述了2型半胱氨酸蛋白酶抑制剂在免疫调节和肿瘤发生发展中的作用，阐明了其在维持健康方面的意义。半胱氨酸蛋白酶抑制剂是一个细胞内和细胞外蛋白酶抑制剂家族，其抑制半胱氨酸组织蛋白酶-一组溶酶体半胱氨酸蛋白酶，其参与多种生物过程，包括蛋白质降解和翻译后切割。半胱氨酸组织蛋白酶与自身免疫性疾病、肿瘤进展和转移的发展相关。胱氨酸蛋白酶抑制剂分为三个亚家族：1型、2型和3型。2型半胱氨酸蛋白酶抑制剂亚家族是最大的，包含10个成员，并且完全由小的分泌蛋白组成。虽然2型半胱氨酸蛋白酶抑制剂具有许多共同的生物学作用，但每个成员在结构、翻译后修饰（例如，糖基化）和在不同细胞类型中的表达。这些区别使得2型半胱氨酸蛋白酶抑制剂具有独特的生物学功能和性质。本文综述了2型半胱氨酸蛋白酶抑制剂，包括它们的生物学相似性和差异，它们对人体免疫反应的调节作用，以及它们在肿瘤进展，免疫逃避和转移中的作用。
Type 2 cystatins are a group of small secreted protease inhibitors that regulate cysteine protease cathepsins and legumain. These enzymes regulate important cellular processes that are linked to the immune response and tumor progression, playing important roles in both autoimmune diseases and various types of cancers. This review aims to explore the roles of type 2 cystatins in immune regulation and cancer development, shedding light on their significance in maintaining health. Cystatins are a family of intracellular and extracellular protease inhibitors that inhibit cysteine cathepsins—a group of lysosomal cysteine proteases that participate in multiple biological processes, including protein degradation and post-translational cleavage. Cysteine cathepsins are associated with the development of autoimmune diseases, tumor progression, and metastasis. Cystatins are categorized into three subfamilies: type 1, type 2, and type 3. The type 2 cystatin subfamily is the largest, containing 10 members, and consists entirely of small secreted proteins. Although type 2 cystatins have many shared biological roles, each member differs in structure, post-translational modifications (e.g., glycosylation), and expression in different cell types. These distinctions allow the type 2 cystatins to have unique biological functions and properties. This review provides an overview of type 2 cystatins, including their biological similarities and differences, their regulatory effect on human immune responses, and their roles in tumor progression, immune evasion, and metastasis.
登录
查看更多内容
DOI：
10.1158/1078-0432.ccr-17-1663
发表时间：
2018-02-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Berger MD;Stintzing S;Heinemann V;Cao S;Yang D;Sunakawa Y;Matsusaka S;Ning Y;Okazaki S;Miyamoto Y;Suenaga M;Schirripa M;Hanna DL;Soni S;Puccini A;Zhang W;Cremolini C;Falcone A;Loupakis F;Lenz HJ
通讯作者：
Lenz HJ
影响因子：
3.8
作者：
Baron, AC;DeCarlo, AA;Featherstone, JDB
通讯作者：
Featherstone, JDB
影响因子：
9
作者：
通讯作者：
--
Cystatin SN 的表达与手术切除的非小细胞肺癌患者的复发、转移和生存时间显着相关
影响因子：
4.6
作者：
Cao X;Li Y;Luo RZ;Zhang L;Zhang SL;Zeng J;Han YJ;Wen ZS
通讯作者：
Wen ZS
影响因子：
37.3
作者：
Baniwal SK;Khalid O;Gabet Y;Shah RR;Purcell DJ;Mav D;Kohn-Gabet AE;Shi Y;Coetzee GA;Frenkel B
通讯作者：
Frenkel B