Functional Magnetic Resonance Imaging (fMRI) of Neural Responses to Visual and Auditory Food Stimuli Pre and Post Roux-en-Y Gastric Bypass (RYGB) and Sleeve Gastrectomy (SG).
Functional Magnetic Resonance Imaging (fMRI) of Neural Responses to Visual and Auditory Food Stimuli Pre and Post Roux-en-Y Gastric Bypass (RYGB) and Sleeve Gastrectomy (SG).
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DOI：
10.1016/j.neuroscience.2019.01.061
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发表时间：
2019-06-15
期刊：
影响因子：
3.3
通讯作者：
Geliebter A
中科院分区：
文献类型：
--
作者：
Baboumian S;Pantazatos SP;Kothari S;McGinty J;Holst J;Geliebter A
Of current obesity treatments, bariatric surgery induces the most weight loss. Given the marked increase in the number of bariatric surgeries performed, elucidating the mechanisms of action is a key research goal. We compared whole brain activation in response to high-energy dense (HED) vs. low-energy dense (LED) visual and auditory food cues before and approximately 4 months after Roux-en-Y Gastric Bypass (RYGB) (n=16) and Sleeve Gastrectomy (SG) (n=9). We included two control groups: a low-calorie diet weight loss group (WL) (n=14) and a non-treatment group (NT) (n=16). Relative to the control groups, the surgery groups showed increased dorsolateral prefrontal cortex (dlPFC) and decreased parahippocampal/fusiform gyrus (PHG/fusiform) activation in response to HED vs. LED, suggesting greater cognitive dietary inhibition and decreased rewarding effects and attention related to HED foods. dlPFC activation was significantly more increased in RYGB vs. SG. We also found that postprandial increases in GLP-1 concentrations (pre to postsurgery) correlated with postsurgical decreases in RYGB brain activity in the inferior temporal gyrus and the right middle occipital gyrus and with increases in the right medial prefrontal gyrus/paracingulate for HED > LED stimuli, suggesting involvement of these attention and inhibitory regions in satiety signaling postsurgery.
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影响因子：
2.9
作者：
Lager, Corey J.;Esfandiari, Nazanene H.;Oral, Elif A.
通讯作者：
Oral, Elif A.
DOI：
10.1002/oby.21464
发表时间：
2016-05
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Faulconbridge LF;Ruparel K;Loughead J;Allison KC;Hesson LA;Fabricatore AN;Rochette A;Ritter S;Hopson RD;Sarwer DB;Williams NN;Geliebter A;Gur RC;Wadden TA
通讯作者：
Wadden TA
影响因子：
5.4
作者：
Geliebter A;Benson L;Pantazatos SP;Hirsch J;Carnell S
通讯作者：
Carnell S
影响因子：
5.4
作者：
Kishinevsky, Felix I.;Cox, James E.;Weller, Rosalyn E.
通讯作者：
Weller, Rosalyn E.
影响因子：
3
作者：
Clemens B;Regenbogen C;Koch K;Backes V;Romanczuk-Seiferth N;Pauly K;Shah NJ;Schneider F;Habel U;Kellermann T
通讯作者：
Kellermann T