Association between melanopsin gene polymorphism (I394T) and pupillary light reflex is dependent on light wavelength.
Association between melanopsin gene polymorphism (I394T) and pupillary light reflex is dependent on light wavelength.
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DOI：
10.1186/1880-6805-32-16
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发表时间：
2013-10-12
影响因子：
3.1
通讯作者：
Higuchi S
中科院分区：
文献类型：
--
作者：
Lee SI;Hida A;Tsujimura S;Morita T;Mishima K;Higuchi S
我们的目的是确定黑视素基因多态性与不同光条件下瞳孔光反射的关系，包括不同的光强和波长。195名视力矫正者自愿参与rs1079610 （I394T）单核苷酸多态性（SNP）黑视素基因调查。基因型组分别为TT （n = 126）、TC （n = 55）和CC (n = 8)，其中TT （n = 34）、TC （n = 33）和CC （n = 8）共75例受试者参加了本实验。制备了峰值波长为465 nm（蓝色）、536 nm（绿色）和632 nm（红色）的三束单色光，分别以12、13、14、14.5和15对数光子/(cm2 s) 5种强度投射到受试者身上，持续1分钟。适应1分钟后，在每种光照条件下测量左眼瞳孔大小。在15 log光子/(cm2 s)蓝光（463 nm）条件下，TC + CC基因型（n = 38）的瞳孔显著小于TT基因型（n = 31） （P < 0.05）。相比之下，绿光（536 nm）和红光（632 nm）条件下无显著差异。相反，在蓝色和绿色高强度条件下（14.5和15对数光子/(cm2 s)）， TC + CC基因型的相对瞳孔收缩均大于TT基因型。在红光照射下，不同基因型组间瞳孔大小和瞳孔相对收缩无显著差异。我们的研究结果表明，黑视素基因多态性（I394T）与瞳孔光反射的功能相互作用取决于光强，特别是波长，并且在高强度和短波长的光条件下，C等位基因（TC + CC）的瞳孔光反应比TT基因型的瞳孔光反应更敏感。
Our aim was to determine the association between melanopsin gene polymorphism and pupillary light reflex under diverse photic conditions, including different intensities and wavelengths. A total of 195 visually corrected subjects volunteered for investigation of the melanopsin gene of single nucleotide polymorphism (SNP) of rs1079610 (I394T). The genotype groups were TT (n = 126), TC (n = 55), and CC (n = 8), and 75 of the subjects, including subjects with TT (n = 34), TC (n = 33), and CC (n = 8) participated in our experiment. Three monochromatic lights with peak wavelengths of 465 nm (blue), 536 nm (green), and 632 nm (red) were prepared, and each light was projected to the subjects with five intensities, 12, 13, 14, 14.5 and 15 log photons/(cm2 s), for one minute. The pupil size of the left eye was measured under each light condition after a 1-minute adaptation. The pupils of the TC + CC genotypes (n = 38) were significantly smaller than those of the TT genotype (n = 31) under a blue (463 nm) light condition with 15 log photons/(cm2 s) (P < 0.05). In contrast, there were no significant differences under green (536 nm) and red (632 nm) light conditions. Conversely, relative pupil constrictions of the TC + CC genotypes were greater than those of the TT genotype under both blue and green conditions with high intensities (14.5 and 15 log photons/(cm2 s)). In contrast, there were no significant differences between genotype groups in pupil size and relative pupilloconstriction under the red light conditions. Our findings suggest that the melanopsin gene polymorphism (I394T) functionally interacts with pupillary light reflex, depending on light intensity and, particularly, wavelength, and that under a light condition fulfilling both high intensity and short wavelength, the pupillary light response of subjects with the C allele (TC + CC) is more sensitive to light than that of subjects with the TT genotype.
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影响因子：
3.7
作者：
Brown TM;Allen AE;al-Enezi J;Wynne J;Schlangen L;Hommes V;Lucas RJ
通讯作者：
Lucas RJ
影响因子：
3.5
作者：
al Enezi, Jazi;Revell, Victoria;Lucas, Robert
通讯作者：
Lucas, Robert
影响因子：
7.4
作者：
Goel, N;Terman, M;Terman, JS
通讯作者：
Terman, JS
影响因子：
3.1
作者：
Katsuura T;Ochiai Y;Senoo T;Lee S;Takahashi Y;Shimomura Y
通讯作者：
Shimomura Y
影响因子：
64.8
作者：
Dacey, DM;Liao, HW;Gamlin, PD
通讯作者：
Gamlin, PD