Prevalence of autoimmune diseases and other associated conditions in children and young adults with juvenile idiopathic arthritis.
Prevalence of autoimmune diseases and other associated conditions in children and young adults with juvenile idiopathic arthritis.
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DOI：
10.1136/rmdopen-2020-001435
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发表时间：
2021-03
期刊：
影响因子：
6.2
通讯作者：
Brunner HI
中科院分区：
文献类型：
--
作者：
Lovell DJ;Huang B;Chen C;Angeles-Han ST;Simon TA;Brunner HI
许多自身免疫性疾病具有共同的致病机制；然而，量化幼年特发性关节炎 (JIA) 患者自身免疫性疾病和相关病症共存的研究有限。这项位于美国的大型研究估计并比较了幼年特发性关节炎患者与一般儿科 (GP) 患者群体中多种共存自身免疫性疾病的患病率。这项回顾性队列研究是使用辛辛那提儿童医院医疗中心的注册数据（2010 年 1 月至 2018 年 10 月）进行的。对 JIA 患者（年龄 <21 岁）和全科医生患者群体中的对照组的多种自身免疫性疾病的患病率进行了估计。使用贝叶斯泊松回归模型对截至研究期结束前每年 26 种预先指定的自身免疫性疾病和相关病症的粗略患病率进行比较。总体而言，JIA 队列中包括 2026 名患者，GP 队列中包括 41 572 名患者。在评估的 26 种自身免疫性疾病和相关病症中，与 GP 队列相比，JIA 队列中有 14 种（53.8%）的患病率显着更高。与 GP 队列相比，JIA 队列中总共有 7 种 (26.9%) 自身免疫性疾病或相关病症的患病率增加了 20 倍以上。在这项研究中，与全科医生人群相比，幼年特发性关节炎患者更容易同时患有多种自身免疫性疾病和相关疾病。医生在治疗和管理幼年特发性关节炎患者时应考虑并存的自身免疫性疾病。
Many autoimmune diseases share common pathogenic mechanisms; however, there are limited studies quantifying the coexistence of autoimmune diseases and associated conditions in patients with juvenile idiopathic arthritis (JIA). This large US-based study estimated and compared the prevalence of multiple coexisting autoimmune diseases in patients with JIA with a general paediatric (GP) patient population. This retrospective cohort study was conducted using registry data from the Cincinnati Children’s Hospital Medical Center (January 2010–October 2018). The prevalence of multiple autoimmune diseases was estimated in patients (age <21 years) with JIA and a control group from the GP patient population. Crude prevalences of 26 prespecified autoimmune diseases and associated conditions were compared using Bayesian Poisson regression modelling for each year up to the end of the study period. Overall, 2026 patients were included in the JIA cohort and 41 572 in the GP cohort. Of 26 autoimmune diseases and associated conditions evaluated, 14 (53.8%) had a significantly higher prevalence in the JIA cohort compared with the GP cohort. In total, seven (26.9%) autoimmune diseases or associated conditions had a >20-fold increased prevalence in the JIA cohort compared with the GP cohort. In this study, patients with JIA had a greater prevalence of a large number of coexisting autoimmune diseases and associated conditions compared with the GP population. Physicians should consider coexisting autoimmune diseases in the treatment and management of patients with JIA.
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影响因子：
5.1
作者：
Schenck, Sandra;Rosenbauer, Joachim;Thon, Angelika
通讯作者：
Thon, Angelika
DOI：
10.3899/jrheum.120661
发表时间：
2013-07
期刊：
The Journal of rheumatology
影响因子：
--
作者：
Harrold LR;Salman C;Shoor S;Curtis JR;Asgari MM;Gelfand JM;Wu JJ;Herrinton LJ
通讯作者：
Herrinton LJ
影响因子：
3.6
作者：
Tronconi E;Miniaci A;Pession A
通讯作者：
Pession A
影响因子：
5.1
作者：
Hermann, Gerhard;Thon, Angelika;Holl, Reinhard W.
通讯作者：
Holl, Reinhard W.
对多发性硬化症中自身免疫性疾病的发病率和患病率进行系统的综述。
DOI：
10.1177/1352458514564490
发表时间：
2015-03
期刊：
Multiple sclerosis (Houndmills, Basingstoke, England)
影响因子：
--
作者：
Marrie RA;Reider N;Cohen J;Stuve O;Sorensen PS;Cutter G;Reingold SC;Trojano M
通讯作者：
Trojano M