Changing Epidemiology of COVID-19 in Children and Adolescents Over Four Successive Epidemic Waves in South Africa, 2020-2022.
Changing Epidemiology of COVID-19 in Children and Adolescents Over Four Successive Epidemic Waves in South Africa, 2020-2022.
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DOI：
10.1093/jpids/piad002
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发表时间：
2023-04-18
影响因子：
3.2
通讯作者：
中科院分区：
文献类型：
--
作者：
南非经历了四波SARS-CoV-2感染，主要是武汉-胡、贝塔、达美和奥美康(BA.1/BA.2)。我们描述了南非儿童和青少年在连续几波SARS-CoV-2检测、病例、入院和死亡方面的趋势。我们分析了2020年3月至2022年2月的全国SARS-CoV-2检测、病例和入院数据，并估计了每个终点按年龄组的累积发病率。第三波和第四波的严重程度用多变量Logistic回归进行评估。18岁的个人≤占总人口的35%(21,008,060,142,978)，但只占病例的12%(424,394/3,593,644)和入院人数的6%(26,176/451,753)。在≤18岁的个体中，婴儿的入院率最高(505/100,000)。在所有年龄组中，第二波(Beta波)和第三波(Delta波)的测试、病例和录取率普遍依次上升。在第四波(Omicron BA.1/BA.2)中，一年内≥患者的发病率下降，而一年内的发病率上升。在第四波中，一岁以下儿童的周入院率(169/100,000)超过了成人(124/100,000)。在每个年龄组中，所有入院病例中发生严重新冠肺炎的几率在第四波比第三波低，但至少有一种并发症的入院病例的严重新冠肺炎的几率是没有并发症的病例的两倍。在第四波中，5岁以下儿童的入院率高于前几波，但总体结果没有那么严重。然而，至少有一种共病的儿童患严重疾病的几率增加，因此有理由考虑优先接种这一群体。
South Africa experienced four waves of SARS-CoV-2 infection, dominated by Wuhan-Hu, Beta, Delta, and Omicron (BA.1/BA.2). We describe the trends in SARS-CoV-2 testing, cases, admissions, and deaths among children and adolescents in South Africa over successive waves. We analyzed national SARS-CoV-2 testing, case, and admissions data from March 2020 to February 2022 and estimated cumulative rates by age group for each endpoint. The severity in the third versus the fourth wave was assessed using multivariable logistic regression. Individuals ≤18 years comprised 35% (21,008,060/60,142,978) of the population but only 12% (424,394/3,593,644) of cases and 6% (26,176/451,753) of admissions. Among individuals ≤18 years, infants had the highest admission (505/100,000) rates. Testing, case, and admission rates generally increased successively in the second (Beta) and third (Delta) waves among all age groups. In the fourth (Omicron BA.1/BA.2) wave, the case rate dropped among individuals ≥1 year but increased among those <1 year. Weekly admission rates for children <1 year (169/100,000) exceeded rates in adults (124/100,000) in the fourth wave. The odds of severe COVID-19 in all admitted cases were lower in the fourth wave versus the third wave in each age group, but they were twice as high in admitted cases with at least one comorbidity than those without. The admission rate for children <5 years was higher in the fourth wave than in previous waves, but the overall outcomes were less severe. However, children with at least one comorbidity had increased odds of severe disease, warranting consideration of prioritizing this group for vaccination.
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影响因子：
4.4
作者：
Kufa, Tendesayi;Jassat, Waasila;Cohen, Cheryl;Tempia, Stefano;Masha, Maureen;Wolter, Nicole;Walaza, Sibongile;Gottburg, Anne;Govender, Nelesh P.;Hunt, Gillian;Shonhiwa, Andronica Moipone;Ebonwu, Joy;Ntshoe, Genevie;Maruma, Wellington;Bapela, Poncho;Ndhlovu, Nomathamsanqa;Mathema, Hlengani;Modise, Motshabi;Shuping, Liliwe;Manana, Pinky N.;Moore, David;Dangor, Ziyaad;Verwey, Charl;Madhi, Shabir A.;Saloojee, Haroon;Zar, Heather J.;Blumberg, Lucille
通讯作者：
Blumberg, Lucille
DOI：
10.1016/s2352-4642(22)00027-x
发表时间：
2022-05
期刊：
The Lancet. Child & adolescent health
影响因子：
--
作者：
Cloete J;Kruger A;Masha M;du Plessis NM;Mawela D;Tshukudu M;Manyane T;Komane L;Venter M;Jassat W;Goga A;Feucht U
通讯作者：
Feucht U
南非第三波感染后的 SARS-CoV-2 血清阳性率。
影响因子：
11.8
作者：
通讯作者：
--
DOI：
10.1016/j.ijid.2020.12.086
发表时间：
2021-03
期刊：
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
影响因子：
--
作者：
Fernández-Rojas MA;Luna-Ruiz Esparza MA;Campos-Romero A;Calva-Espinosa DY;Moreno-Camacho JL;Langle-Martínez AP;García-Gil A;Solís-González CJ;Canizalez-Román A;León-Sicairos N;Alcántar-Fernández J
通讯作者：
Alcántar-Fernández J
影响因子：
11.8
作者：
McMorrow, Meredith L.;Tempia, Stefano;Cohen, Cheryl
通讯作者：
Cohen, Cheryl