Transcranial Magnetic Resonance-Guided Histotripsy for Brain Surgery: Pre-clinical Investigation.
Transcranial Magnetic Resonance-Guided Histotripsy for Brain Surgery: Pre-clinical Investigation.
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DOI：
10.1016/j.ultrasmedbio.2021.09.008
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发表时间：
2022-01
影响因子：
2.9
通讯作者：
Xu, Zhen
中科院分区：
文献类型：
--
作者：
Lu, Ning;Gupta, Dinank;Daou, Badih J.;Fox, Adam;Choi, Dave;Sukovich, Jonathan R.;Hall, Timothy L.;Camelo-Piragua, Sandra;Chaudhary, Neeraj;Snell, John;Pandey, Aditya S.;Noll, Douglas C.;Xu, Zhen
组织摩擦学先前已经被应用于通过切除的人类头骨在体外靶向不同的颅骨位置。最近，开发了一种经颅磁共振(MR)引导的组织学(TcMRgHt)系统，使脑外科tcMRgHt的临床前研究成为可能。为了确定活体经颅组织摩擦学的可行性，在3-T磁共振成像(MRI)扫描仪内使用700 kHz、128元件、MR兼容的相控阵换能器对8头猪进行tcMRgHt治疗。在开颅术打开通往大脑的声学窗口后，根据治疗前的MRI和基准标记，通过切除的人颅骨对猪大脑内部进行组织摩擦检查。分别于治疗前、治疗后即刻、治疗后2~4h采集MRI图像，评价急性治疗效果。所有的猪都观察到了成功的组织学消融。MR显示的病变被很好地限制在目标体积内，没有证据表明靶区外有过度的脑水肿或出血。组织学显示消融区组织均质化，破坏的组织和未受影响的组织之间有明显的分界，这与MRI上的放射治疗区域有很好的相关性。这些结果首次支持了tcMRgHt在猪脑中的体内可行性，为进一步研究tcMRgHt在脑外科的应用奠定了基础。
Histotripsy has been previously applied to target various cranial locations in vitro through an excised human skull. Recently, a transcranial magnetic resonance (MR)-guided histotripsy (tcMRgHt) system was developed, enabling pre-clinical investigations of tcMRgHt for brain surgery. To determine the feasibility of in vivo transcranial histotripsy, tcMRgHt treatment was delivered to eight pigs using a 700-kHz, 128-element, MR-compatible phased-array transducer inside a 3-T magnetic resonance imaging (MRI) scanner. After craniotomy to open an acoustic window to the brain, histotripsy was applied through an excised human calvarium to target the inside of the pig brain based on pre-treatment MRI and fiducial markers. MR images were acquired pre-treatment, immediately post-treatment and 2–4 h post-treatment to evaluate the acute treatment outcome. Successful histotripsy ablation was observed in all pigs. The MR-evident lesions were well confined within the targeted volume, without evidence of excessive brain edema or hemorrhage outside of the target zone. Histology revealed tissue homogenization in the ablation zones with a sharp demarcation between destroyed and unaffected tissue, which correlated well with the radiographic treatment zones on MRI. These results are the first to support the in vivo feasibility of tcMRgHt in the pig brain, enabling further investigation of the use of tcMRgHt for brain surgery.
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DOI：
10.1109/tuffc.2014.2947
发表时间：
2014-04-01
影响因子：
3.6
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