Gypenosides protected the neural stem cells in the subventricular zone of neonatal rats that were prenatally exposed to ethanol.
Gypenosides protected the neural stem cells in the subventricular zone of neonatal rats that were prenatally exposed to ethanol.
复制标题
DOI：
10.3390/ijms151221967
复制
发表时间：
2014-11-28
影响因子：
5.6
通讯作者：
Wang XJ
中科院分区：
文献类型：
--
作者：
Dong L;Yang KQ;Fu WY;Shang ZH;Zhang QY;Jing FM;Li LL;Xin H;Wang XJ
胎儿酒精谱系障碍(FASD)可导致产前接触乙醇的儿童严重的智力低下。已经研究了出生前和出生后早期酒精暴露对成年海马神经发生的影响；然而，出生前酒精暴露对脑室下区(SVZ)的影响尚未见报道。绞股蓝总皂苷(Gypenoside，GP)除了具有其他生物活性外，还具有神经保护作用。在FASD模型中，GP对神经干细胞(NSCs)的影响尚不清楚。在这里，我们测试了产前酒精暴露对新生SVZ的影响，以及GPs对FASD大鼠神经干细胞的保护作用。结果表明，孕期酒精暴露可抑制新生SVZ神经干细胞的增殖和分化，GPS(400 mg/kg/d)可明显促进乙醇抑制的神经干细胞的增殖和分化。本实验结果表明，人参总皂甙对NSCs具有神经保护作用，并能增强乙醇抑制的新生大鼠SVZ内的神经发生。这些发现为全科医生治疗FASD的潜在疗法提供了新的证据。
Fetal alcohol spectrum disorder (FASD) can cause severe mental retardation in children who are prenatally exposed to ethanol. The effects of prenatal and early postnatal ethanol exposure on adult hippocampal neurogenesis have been investigated; however, the effects of prenatal ethanol exposure on the subventricular zone (SVZ) have not. Gypenosides (GPs) have been reported to have neuroprotective effects in addition to other bioactivities. The effects of GPs on neural stem cells (NSCs) in the FASD model are unknown. Here, we test the effect of prenatal ethanol exposure on the neonatal SVZ, and the protection potential of GPs on NSCs in FASD rats. Our results show that prenatal ethanol exposure can suppress the cell proliferation and differentiation of neural stem cells in the neonatal SVZ and that GPs (400 mg/kg/day) can significantly increase the cell proliferation and differentiation of neural stem cells inhibited by ethanol. Our data indicate that GPs have neuroprotective effects on the NSCs and can enhance the neurogenesis inhibited by ethanol within the SVZ of neonatal rats. These findings provide new evidence for a potential therapy involving GPs for the treatment of FASD.
登录
查看更多内容
影响因子：
3.7
作者：
Miranda RC
通讯作者：
Miranda RC
DOI：
10.1111/j.1530-0277.2011.01682.x
发表时间：
2012-05-01
影响因子：
3.2
作者：
Vangipuram, Sharada D.;Lyman, William D.
通讯作者：
Lyman, William D.
影响因子：
56.9
作者：
Gould, E;Reeves, AJ;Gross, CG
通讯作者：
Gross, CG
影响因子：
2.5
作者：
Brown, JP;Couillard-Després, S;Kuhn, HG
通讯作者：
Kuhn, HG
影响因子：
16.2
作者：
LUSKIN, MB
通讯作者：
LUSKIN, MB