Up‐regulation of astrocyte excitatory amino acid transporter 2 alleviates central sensitization in a rat model of chronic migraine

Up‐regulation of astrocyte excitatory amino acid transporter 2 alleviates central sensitization in a rat model of chronic migraine
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星形胶质细胞兴奋性氨基酸转运蛋白 2 的上调可减轻慢性偏头痛大鼠模型的中枢敏化

DOI:
10.1111/jnc.14944
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发表时间:
2019-12
影响因子:
4.7
通讯作者:
Lixue Chen
Lixue Chen
中科院分区:
医学2区
文献类型:
--
作者:
Xue Zhou;Jie Liang;Jiang Wang;Zhaoyang Fei;Guangcheng Qin;Dunke Zhang;Jiying Zhou;Lixue Chen

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中枢敏化是慢性偏头痛(CM)的潜在发病机制,与持续的神经元过度兴奋有关。兴奋性氨基酸转运蛋白 2 (EAAT2) 功能障碍导致谷氨酸在突触间隙积聚,
Central sensitization is the potential pathogenesis of chronic migraine (CM) and is related to persistent neuronal hyperexcitability. Dysfunction of excitatory amino acid transporter 2 (EAAT2) leads to the accumulation of glutamate in the synaptic cleft,
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