Short-latency afferent inhibition is a poor predictor of individual susceptibility to rTMS-induced plasticity in the motor cortex of young and older adults.
Short-latency afferent inhibition is a poor predictor of individual susceptibility to rTMS-induced plasticity in the motor cortex of young and older adults.
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DOI：
10.3389/fnagi.2014.00182
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发表时间：
2014
影响因子：
4.8
通讯作者：
Tremblay F
中科院分区：
文献类型：
--
作者：
Young-Bernier M;Tanguay AN;Davidson PS;Tremblay F
皮质可塑性，包括长时程增强（LTP）样可塑性，可以用重复经颅磁刺激（rTMS）方案进行非侵入性评估。在这项研究中，我们研究了20名年轻人和18名健康老年人对间歇性Theta爆发刺激（iTBS）反应的年龄差异。由于胆碱能系统在学习和记忆（包括LTP）的神经过程中发挥作用，我们还研究了短潜伏期传入抑制（SAI）（中枢胆碱能活动的神经生理学标志物）是否与iTBS诱导的LTP样可塑性的年龄相关差异相关。研究方法：SAI首先通过检查运动诱发电位（MEP）在TMS前20 ms对正中神经条件反射的调制来评估。然后参与者接受iTBS（每200 ms以50 Hz的频率进行3次脉冲，持续2 s，列车之间间隔8 s，重复20次）。在iTBS后立即和应用后5、10和20分钟评估MEP反应（120%静息运动阈值（RMT））。结果如下：两个年龄组对iTBS的反应差异很大，只有大约60%的参与者（n = 13名年轻人和10名老年人）显示出预期的MEP反应促进作用。iTBS后MEP易化无显著年龄组差异。虽然老年人表现出减少SAI，个体差异与iTBS后表达LTP样诱导可塑性的易感性无关。结论：总体而言，这些结果与iTBS应答的高个体间变异性报告一致。尽管SAI在老年人中降低，与胆碱能系统随年龄的恶化一致，但SAI水平与iTBS评估的LTP样可塑性无关。
Cortical plasticity, including long-term potentiation (LTP)-like plasticity, can be assessed non-invasively with repetitive transcranial magnetic stimulation (rTMS) protocols. In this study, we examined age differences in responses to intermittent theta burst stimulation (iTBS) in a group of 20 young and 18 healthy older adults. Because the cholinergic system plays a role in the neural processes underlying learning and memory, including LTP, we also investigated whether short latency afferent inhibition (SAI), a neurophysiological marker of central cholinergic activity, would be associated with age-related differences in LTP-like plasticity induced by iTBS. Methods: SAI was first assessed by examining the modulation of motor evoked potentials (MEPs) in response to median nerve conditioning 20 ms prior to TMS. Participants then underwent iTBS (3 pulses at 50 Hz every 200 ms for 2 s with 8 s between trains, repeated 20 times). MEP responses (120% resting motor threshold (RMT)) were assessed immediately after iTBS and 5, 10, and 20 min post-application. Results: Responses to iTBS were quite variable in both age groups, with only approximately 60% of the participants (n = 13 young and 10 older adults) showing the expected facilitation of MEP responses. There were no significant age group differences in MEP facilitation following iTBS. Although older adults exhibited reduced SAI, individual variations were not associated with susceptibility to express LTP-like induced plasticity after iTBS. Conclusion: Overall, these results are consistent with reports of high inter-individual variability in responses to iTBS. Although SAI was reduced in older adults, consistent with a deterioration of the cholinergic system with age, SAI levels were not associated with LTP-like plasticity as assessed with iTBS.
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