Total vs. Bioavailable: Determining a Better 25(OH)D Index in Association with Bone Density and Muscle Mass in Postmenopausal Women.
Total vs. Bioavailable: Determining a Better 25(OH)D Index in Association with Bone Density and Muscle Mass in Postmenopausal Women.
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DOI：
10.3390/metabo11010023
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发表时间：
2020-12-31
期刊：
影响因子：
4.1
通讯作者：
Mitra SR
中科院分区：
文献类型：
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作者：
Abidin NZ;Mitra SR
老年人同时存在低骨密度（骨量减少/骨质疏松症）和低肌肉质量（肌肉减少症），导致将“骨减少症”（OS）视为单一实体。维生素D可能在OS的表现中发挥重要作用，在摄入，吸收和生物利用度方面。有证据表明，与总25（OH）D相比，生物可利用的25（OH）D可能是维生素D的更好指标，因为其与白蛋白的结合较弱，增加了其“可用性”。本研究的目的是评估绝经后妇女的总的和生物可利用的25（OH）D水平，并确定其与骨密度和肌肉质量的关系。我们评估身体成分，骨密度和25（OH）D指数的多种族，绝经后的马来西亚妇女。体脂%与25（OH）D各指标呈显著负相关。生物利用度和总25（OH）D与血钙呈正相关，与全段甲状旁腺激素（iPTH）呈负相关。维生素D结合蛋白（VDBP）水平与生物可利用25（OH）D水平显著相关，而与总25（OH）D水平无相关性。逐步回归分析显示，生物可利用的，但不是总的，25（OH）D是显着相关的骨密度和肌肉质量，（其中更强的相关性被发现与骨密度），这表明其优越性。然而，低效应量需要进一步研究。
The concurrent presence of low bone density (osteopenia/osteoporosis) and low muscle mass (sarcopenia) in older adults has led to the recognition of “osteosarcopenia” (OS) as a singular entity. Vitamin D may play important role in the manifestation of OS, in terms of intake, absorption, and bioavailability. Evidence suggests that bioavailable 25(OH)D may be a better indicator of Vitamin D compared to total 25(OH)D due to its weak bind to albumin, increasing its ‘availability’. The aim of this study was to assess total and bioavailable 25(OH)D levels in postmenopausal women and to determine their associations to bone density and muscle mass. We assessed body composition, bone density, and 25(OH)D indices of multiethnic, postmenopausal Malaysian women. A significant and negative correlation was found between body fat % and each index of 25(OH)D. Both bioavailable and total 25(OH)D were positively correlated with serum calcium and negatively correlated with iPTH(intact parathyroid hormone). VDBP(Vitamin D binding protein) level was significantly correlated with bioavailable 25(OH)D level, but not with the total 25(OH)D level. Stepwise regression analysis revealed that bioavailable, but not total, 25(OH)D was significantly correlated to bone density and muscle mass, (where stronger correlation was found with bone density), suggesting its superiority. Nevertheless, the low effect size warrants further studies.
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影响因子：
5.8
作者：
Ahern, T.;Khattak, A.;O'Shea, D.
通讯作者：
O'Shea, D.
DOI：
10.1093/gerona/glx086
发表时间：
2018-01-01
影响因子：
5.1
作者：
Hirani, Vasant;Cumming, Robert G.;Seibel, Markus J.
通讯作者：
Seibel, Markus J.
影响因子：
4.8
作者：
Abboud, M.;Puglisi, D. A.;Mason, R. S.
通讯作者：
Mason, R. S.
影响因子：
9.3
作者：
Heijboer, Annemieke C.;Blankenstein, Marinus A.;Buijs, Madelon M.
通讯作者：
Buijs, Madelon M.
影响因子：
19.6
作者：
通讯作者：
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