Multifunctional to multistage delivery systems: The evolution of nanoparticles for biomedical applications.
Multifunctional to multistage delivery systems: The evolution of nanoparticles for biomedical applications.
复制标题
DOI：
10.1007/s11434-012-5387-5
复制
发表时间：
2012-11-01
影响因子：
--
通讯作者：
Tasciotti, Ennio
中科院分区：
文献类型：
--
作者：
Martinez, Jonathan O.;Brown, Brandon S.;Quattrocchi, Nicoletta;Evangelopoulos, Michael;Ferrari, Mauro;Tasciotti, Ennio
关键词：
纳米材料正在向多个方向发展，在合成、功能化和生物医学应用方面取得了重大进展。在这篇综述中，我们将描述几类原型纳米载体，例如脂质体、硅颗粒和金纳米壳，它们的单独功能以及协同用途。主动和被动靶向、光热消融和药物控制释放构成了实现医疗目的的一些关键功能。目前在靶向、缓慢清除以及全身和局部毒性方面的局限性是参考最近试图理解和解决这些问题的研究来解决的。这一讨论的基础是需要更深入地了解纳米材料对身体的影响及其潜在的免疫反应。然后在多功能纳米载体的背景下讨论组合组件，多功能纳米载体是我们在过去 5 年中设想、提出和发展的一类药物输送系统。特别是，我们的第三代纳米载体，即多级载体，通过将多种成分组合到具有新兴特性并能够实现协同效应的多功能纳米载体上，开创了纳米医学的新领域。
Nanomaterials are advancing in several directions with significant progress being achieved with respect to their synthesis, functionalization and biomedical application. In this review, we will describe several classes of prototypical nanocarriers, such as liposomes, silicon particles, and gold nanoshells, in terms of their individual function as well as their synergistic use. Active and passive targeting, photothermal ablation, and drug controlled release constitute some of the crucial functions identified to achieve a medical purpose. Current limitations in targeting, slow clearance, and systemic as well as local toxicity are addressed in reference to the recent studies that attempted to comprehend and solve these issues. The demand for a more sophisticated understanding of the impact of nanomaterialson the body and of their potential immune response underlies this discussion. Combined components are then discussed in the setting of multifunctional nanocarriers, a class of drug delivery systems we envisioned, proposed, and evolved in the last 5 years. In particular, our third generation of nanocarriers, the multistage vectors, usher in the new field of nanomedicine by combining several components onto multifunctional nanocarriers characterized by emerging properties and able to achieve synergistic effects.
登录
查看更多内容
DOI：
10.1073/pnas.2232479100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Hirsch, LR;Stafford, RJ;West, JL
通讯作者：
West, JL
影响因子：
29.4
作者：
Canham, LT
通讯作者：
Canham, LT
影响因子：
18.3
作者：
Godin, Biana;Tasciotti, Ennio;Liu, Xuewu;Serda, Rita E.;Ferrari, Mauro
通讯作者：
Ferrari, Mauro
影响因子：
3.8
作者：
Gentile, Francesco;Ferrari, Mauro;Decuzzi, Paolo
通讯作者：
Decuzzi, Paolo
影响因子：
10.8
作者：
Gobin, Andre M.;Lee, Min Ho;West, Jennifer L.
通讯作者：
West, Jennifer L.