Intratympanic Insulin-like Growth Factor-1 Administration Via the Otic Bulla in a Severe Facial Paralysis Model
Intratympanic Insulin-like Growth Factor-1 Administration Via the Otic Bulla in a Severe Facial Paralysis Model
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在严重面瘫模型中通过耳大疱进行鼓室内胰岛素样生长因子-1 给药
DOI：
10.1097/mao.0000000000003263
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发表时间：
2021
影响因子：
2.1
通讯作者：
Hato Naohito
中科院分区：
文献类型：
--
作者：
Kimura Takuya;Yamada Hiroyuki;Teraoka Masato;Joko Tomonori;Iwata Shinji;Tabata Yasuhiro;Wakisaka Hiroyuki;Hato Naohito
背景：使用再生医学涉及生长因子已被报道在周围神经疾病的治疗。IGF-1在神经再生中起着至关重要的作用。正常组（n= 7）不做手术。在生理盐水组（n= 7）和IGF-1组（n= 7）中，通过冷冻面神经管来诱导面瘫。随后，在生理盐水和IGF-1组中，将分别用100 μL生理盐水和400 μg/100 μL IGF-1浸渍的明胶水凝胶置于面神经管中。面神经功能评估使用三个测试电池：面部运动观察，电生理测试，和组织学assessment.Results：在术后10周，IGF-1组的面部运动评分改善与生理盐水组相比。IGF-1组的传导速度明显快于生理盐水组。有一个显着的组间差异的神经纤维的数量和髓鞘thickness.Conclusion：intraytumpanic IGF-1管理面神经再生。这种新的方法可以提供及时的非卧床再生治疗，并减少严重面瘫患者恢复不良的发生率。
Background:The use of regenerative medicine involving growth factors has been reported in the treatment of peripheral nerve diseases. IGF-1 plays a crucial role in nerve regeneration.Methods:We performed the following procedures on guinea pigs. In the normal group (n= 7), no procedure was performed. In the saline (n= 7) and IGF-1 (n= 7) groups, facial paralysis was induced by freezing of the facial canal. Subsequently, in the saline and IGF-1 groups, a gelatin hydrogel impregnated with 100 μL saline and 400 μg/100 μL IGF-1, respectively, was placed in the facial canal. Facial nerve functions were evaluated using three test batteries: facial movement observation, electrophysiological testing, and histological assessment.Results:At 10 weeks postoperatively, the facial movement scores for the IGF-1 group were improved compared to those in the saline group. The conductive velocity was significantly faster in the IGF-1 group than in the saline group. There was a significant between-group difference in the nerve fiber number and myelin thickness.Conclusion:Intratympanic IGF-1 administration improved facial nerve regeneration. This novel method could provide prompt ambulatory regenerative treatment and reduce the incidence of poor recovery in patients with severe facial paralysis.
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影响因子：
2.1
作者：
Hato, Naohito;Yamada, Hiroyuki;Yamakawa, Kazuhiro
通讯作者：
Yamakawa, Kazuhiro
影响因子：
1.4
作者：
Komobuchi, Hayato;Hato, Naohito;Yamamoto, Masaya
通讯作者：
Yamamoto, Masaya
影响因子：
1.7
作者：
Joko, Tomonori;Yamada, Hiroyuki;Hato, Naohito
通讯作者：
Hato, Naohito
贝尔麻痹的自然史。
DOI：
--
发表时间：
1992
期刊：
Acta oto-laryngologica. Supplementum
影响因子：
--
作者：
E. Peitersen
通讯作者：
E. Peitersen
阿昔洛韦加类固醇与单独类固醇治疗贝尔麻痹的比较。
影响因子：
2.5
作者：
S. Yeo;Young Chan Lee;D. Park;C. Cha
通讯作者：
C. Cha