Metal Messengers: Communication in the Bacterial World through Transition-Metal-Sensing Two-Component Systems.
Metal Messengers: Communication in the Bacterial World through Transition-Metal-Sensing Two-Component Systems.
复制标题
DOI：
10.1021/acs.biochem.3c00296
复制
发表时间：
2023-08-15
期刊：
影响因子：
2.9
通讯作者：
Smith, Aaron T.
中科院分区：
文献类型：
--
作者：
Paredes, Alexander;Iheacho, Chioma;Smith, Aaron T.
细菌能在高度动态和复杂的环境中生存，部分原因是存在一些系统，这些系统能在环境刺激不断变化的情况下对基因表达进行快速调控。细胞内和细胞外细菌环境之间的相互作用通常由双组分信号转导系统促进，该系统通常由一个跨膜组氨酸激酶和一个胞质反应调节因子组成。传感器组氨酸激酶和反应调节因子与其包含高度保守结构特征的模块结构域协同工作，以控制对环境变化作出反应的多种基因。细菌的双组分系统广泛存在，并在许多重要过程中发挥关键作用，例如运动性、毒力、趋化性，甚至过渡金属稳态。过渡金属对原核生物的正常生理过程至关重要，如果其水平得到适当控制，这些金属离子的存在也可能影响致病性毒力。为此，细菌利用能结合并对细胞外过渡金属浓度的快速波动作出反应的过渡金属感应双组分系统。本综述总结了细菌过渡金属感应双组分系统的结构和金属结合特征，并特别强调了解病原体如何利用这些系统在宿主细胞中建立感染，以及这些系统如何可能成为未来治疗开发的靶点。
Bacteria survive in highly dynamic and complex environments due, in part, to the presence of systems that allow the rapid control of gene expression in the presence of changing environmental stimuli. The crosstalk between intra- and extracellular bacterial environments is often facilitated by two-component signal transduction systems that are typically composed of a transmembrane histidine kinase and a cytosolic response regulator. Sensor histidine kinases and response regulators work in tandem with their modular domains containing highly conserved structural features to control a diverse array of genes that respond to changing environments. Bacterial two-component systems are widespread and play crucial roles in many important processes, such as motility, virulence, chemotaxis, and even transition metal homeostasis. Transition metals are essential for normal prokaryotic physiological processes, and the presence of these metal ions may also influence pathogenic virulence if their levels are appropriately controlled. To do so, bacteria use transition-metal-sensing two-component systems that bind and respond to rapid fluctuations in extracytosolic concentrations of transition metals. This perspective summarizes the structural and metal-binding features of bacterial transition-metal-sensing two-component systems and places a special emphasis on understanding how these systems are used by pathogens to establish infection in host cells and how these systems may be targeted for future therapeutic developments.
登录
查看更多内容
影响因子：
3.5
作者：
Castegna A;Menga A
通讯作者：
Menga A
影响因子：
4.1
作者：
Affandi, Trisiani;McEvoy, Megan M.
通讯作者：
McEvoy, Megan M.
影响因子：
4.1
作者：
Cantini, Francesca;Banci, Lucia;Solioz, Marc
通讯作者：
Solioz, Marc
影响因子：
3.5
作者：
BEYERSMANN, D
通讯作者：
BEYERSMANN, D
DOI：
10.1073/pnas.87.1.41
发表时间：
1990-01-01
影响因子：
11.1
作者：
BOURRET, RB;HESS, JF;SIMON, MI
通讯作者：
SIMON, MI