Some Good and Some Bad: Sand Fly Salivary Proteins in the Control of Leishmaniasis and in Autoimmunity.
Some Good and Some Bad: Sand Fly Salivary Proteins in the Control of Leishmaniasis and in Autoimmunity.
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DOI：
10.3389/fcimb.2022.839932
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发表时间：
2022
影响因子：
5.7
通讯作者：
Valenzuela JG
中科院分区：
文献类型：
--
作者：
Aoki V;Abdeladhim M;Li N;Cecilio P;Prisayanh P;Diaz LA;Valenzuela JG
沙蝇是一种食血昆虫，负责将媒介传播的疾病传播给人类。这些疾病中最突出的是利什曼病，它影响皮肤和粘膜表面以及肝脏和脾脏等器官。重要的是，吸血节肢动物的功能不仅仅是运送病原体。病媒的唾液含有药理活性成分，促进血液摄食，并经常建立病原体。转录组学和蛋白质组学研究列举了沙蝇唾液蛋白的全部种类及其在控制利什曼病方面的潜在用途，无论是作为媒介暴露的生物标志物还是作为抗利什曼病疫苗。然而，一组特定的沙蝇唾液蛋白触发了交叉反应抗体的形成，这些抗体结合了人桥粒蛋白1（表皮桥粒钙粘蛋白的一员）的外结构域。这些交叉反应性抗体与皮肤自身免疫性水疱疾病有关，如天疱疮，在某些免疫遗传易感个体中。在这篇综述中，我们关注沙蝇唾液蛋白在人类疾病背景下的两个不同方面：好的方面，指的是作为暴露生物标志物或抗利什曼原虫疫苗的唾液蛋白；坏的方面，指的是唾液蛋白作为自身免疫性皮肤病的环境触发因素。
Sand flies are hematophagous insects responsible for the transmission of vector-borne diseases to humans. Prominent among these diseases is Leishmaniasis that affects the skin and mucous surfaces and organs such as liver and spleen. Importantly, the function of blood-sucking arthropods goes beyond merely transporting pathogens. The saliva of vectors of disease contains pharmacologically active components that facilitate blood feeding and often pathogen establishment. Transcriptomic and proteomic studies have enumerated the repertoire of sand fly salivary proteins and their potential use for the control of Leishmaniasis, either as biomarkers of vector exposure or as anti-Leishmania vaccines. However, a group of specific sand fly salivary proteins triggers formation of cross-reactive antibodies that bind the ectodomain of human desmoglein 1, a member of the epidermal desmosomal cadherins. These cross-reactive antibodies are associated with skin autoimmune blistering diseases, such as pemphigus, in certain immunogenetically predisposed individuals. In this review, we focus on two different aspects of sand fly salivary proteins in the context of human disease: The good, which refers to salivary proteins functioning as biomarkers of exposure or as anti-Leishmania vaccines, and the bad, which refers to salivary proteins as environmental triggers of autoimmune skin diseases.
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影响因子：
6.5
作者：
DIAZ, LA;SAMPAIO, SAP;ANHALT, GJ
通讯作者：
ANHALT, GJ
DOI：
10.1111/j.1087-0024.2004.00833.x
发表时间：
2004-01-01
影响因子：
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作者：
Aoki, V;Millikan, RC;Diaz, LA
通讯作者：
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影响因子：
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作者：
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影响因子：
2.7
作者：
Cunha, Jurema M.;Abbehusen, Melissa;Brodskyn, Claudia I.
通讯作者：
Brodskyn, Claudia I.
影响因子：
1.7
作者：
Armiyanti, Yunita;Arifianto, Renam Putra;Sardjono, Teguh Wahju
通讯作者：
Sardjono, Teguh Wahju