Latent growth-curve analysis reveals that worsening Parkinson's disease quality of life is driven by depression.
Latent growth-curve analysis reveals that worsening Parkinson's disease quality of life is driven by depression.
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DOI：
10.1037/neu0000158
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发表时间：
2015-07
期刊：
影响因子：
2.4
通讯作者：
Bowers, Dawn
中科院分区：
文献类型：
--
作者：
Jones, Jacob D.;Marsiske, Michael;Okun, Michael S.;Bowers, Dawn
帕金森病（PD）是一种神经退行性疾病，导致各种各样的症状。本研究探讨了冷漠、抑郁和运动症状对帕金森病患者生活质量的影响。资料取自18个月期间。在3个时间点对参与者（N = 397）的冷漠（冷漠量表）、抑郁（贝克抑郁量表-II）、运动严重程度（统一帕金森病评定量表，第三部分;帕金森病量表）和生活质量（帕金森病问卷-39）进行评估：初始临床评估（基线）、6个月随访和18个月随访。潜在增长曲线模型被用来确定冷漠，抑郁和运动症状对生活质量轨迹的影响。基线时生活质量的困难与更严重的抑郁症状有最强的关系，其次是更严重的运动症状，更年轻的年龄和更少的教育（所有p值<0.001）。18个月期间生活质量恶化仅通过抑郁恶化预测（p = .003）。生活质量和抑郁症状之间的关系仍然显着的非抑郁症PD患者的子样本。总体而言，本研究的结果表明，PD患者自我报告的生活质量主要与抑郁症有关。未来改善PD患者临床护理的努力可能会受益于改善心理社会调整或针对抑郁症的治疗。
Parkinson’s disease (PD) is a neurodegenerative disorder resulting in a wide variety of symptoms. The current study examined the influence of apathy, depression and motor symptoms on quality of life (QoL) in PD patients. Information was drawn from an 18-month period. Participants (N = 397) were assessed for apathy (Apathy Scale), depression (Beck Depression Inventory-II), motor severity (Unified Parkinson’s Disease Rating Scale, Part III; UPDRS), and QoL (Parkinson’s Disease Questionnaire-39) at 3 time points: an initial clinical evaluation (baseline), a 6-month follow-up, and an 18-month follow-up. Latent growth-curve models were used to determine the influence of apathy, depression, and motor symptoms on QoL trajectories. Greater difficulties with QoL at baseline showed the strongest relationship to more severe depression symptoms, followed by more severe motor symptoms, younger age, and less education (all p values < .001). Worsening of QoL over the 18-month period was only predicted by a worsening of depression (p = .003). The relationship between QoL and depression symptoms remained significant in a subsample of nondepressed PD patients. Overall, findings from the current study suggest that self-reported QoL among PD patients is primarily related to depression. Future efforts to improving clinical care of PD patients may benefit by focusing on improving psychosocial adjustment or treatments targeting depression.
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DOI：
10.1080/10705519909540118
发表时间：
1999-01-01
影响因子：
6
作者：
Hu, Li-tze;Bentler, Peter M.
通讯作者：
Bentler, Peter M.
影响因子：
11
作者：
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影响因子：
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Merrilees, Jennifer;Dowling, Glenna A.;Miller, Bruce L.
通讯作者：
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影响因子：
2.4
作者：
Zahodne LB;Marsiske M;Okun MS;Rodriguez RL;Malaty I;Bowers D
通讯作者：
Bowers D
影响因子：
1.4
作者：
Zgaljardic, Dennsis J.;Borod, Joan C.;Eidelberg, David
通讯作者：
Eidelberg, David