Changes in Mortality in People With IGT Before and After the Onset of Diabetes During the 23-Year Follow-up of the Da Qing Diabetes Prevention Study.
Changes in Mortality in People With IGT Before and After the Onset of Diabetes During the 23-Year Follow-up of the Da Qing Diabetes Prevention Study.
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DOI：
10.2337/dc16-0429
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发表时间：
2016-09
期刊：
影响因子：
16.2
通讯作者：
Li G
中科院分区：
文献类型：
--
作者：
Gong Q;Zhang P;Wang J;An Y;Gregg EW;Li H;Zhang B;Shuai Y;Yang W;Chen Y;Liu S;Engelgau MM;Hu Y;Bennett PH;Li G
糖耐量受损（IGT）的人死亡风险增加，进展为糖尿病的风险也很高，但过量死亡率与IGT本身相关的程度还是后续糖尿病的结果尚不清楚。我们比较了542名IGT患者患糖尿病前后的死亡率，这些患者最初参加了一项为期6年的生活方式糖尿病预防试验，并从1986年到2009年进行了随访。在23年的随访期间，174人（32.1%）死亡，总死亡率为15.9/ 1000人年。大多数死亡（74.7%；174例中有130例）发生在进展为2型糖尿病之后，在发生2型糖尿病之前和发展为2型糖尿病之后，年龄调整死亡率分别为11.1/ 1000人年（95% CI 8.2-12.0）和19.4/ 1000人年（95% CI 11.9-23.3）。在前10年随访期间发展为2型糖尿病的参与者的累积死亡率为37.8% (95% CI 33.1-42.2%)，在10 - 20年内发展为2型糖尿病的参与者的累积死亡率为28.6% (95% CI 21.6-35.0%)，在20年内未发展为2型糖尿病的参与者的累积死亡率为13.9% （95% CI 7.0-20.3%）。时间相关的多变量Cox比例风险分析，校正了基线年龄、性别、干预和其他潜在的混杂风险因素，显示2型糖尿病的发生与死亡风险增加73%相关（风险比1.73 [95% CI 1.18-2.52]）。与其他地方一样，在中国，IGT与死亡风险增加有关，但这种额外的风险很大程度上归因于2型糖尿病的发展。
People with impaired glucose tolerance (IGT) have increased risk of mortality and a high risk of progression to diabetes, but the extent that the excess mortality is associated with IGT per se or is the result of subsequent diabetes is unclear. We compared mortality before and after the development of diabetes among 542 persons with IGT initially who participated in a 6-year lifestyle diabetes prevention trial and were followed-up from 1986 to 2009. During the 23-year follow-up, 174 (32.1%) died, with an overall death rate of 15.9/1,000 person-years. The majority of deaths (74.7%; 130 of 174) occurred after progression to type 2 diabetes, with age-adjusted death rates of 11.1/1,000 person-years (95% CI 8.2–12.0) before and 19.4/1,000 person-years (95% CI 11.9–23.3) after the development of type 2 diabetes. The cumulative mortality was 37.8% (95% CI 33.1–42.2%) in participants who developed type 2 diabetes during first 10 years of follow-up, 28.6% (95% CI 21.6–35.0%) in those who progressed to type 2 diabetes in 10–20 years, and 13.9% (95% CI 7.0–20.3%) in those who did not develop to type 2 diabetes within 20 years. Time-dependent multivariate Cox proportional hazards analyses, with adjustment for baseline age, sex, intervention, and other potential confounding risk factors, showed that the development of type 2 diabetes was associated with a 73% higher risk of death (hazard ratio 1.73 [95% CI 1.18–2.52]). As elsewhere, IGT is associated with increased risk of mortality in China, but much of this excess risk is attributable to the development of type 2 diabetes.
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影响因子：
16.2
作者：
An Y;Zhang P;Wang J;Gong Q;Gregg EW;Yang W;Li H;Zhang B;Shuai Y;Chen Y;Engelgau MM;Cheng Y;Hu Y;Bennett PH;Li G
通讯作者：
Li G
影响因子：
105.7
作者：
Huxley, R;Barzi, F;Woodward, M
通讯作者：
Woodward, M
影响因子：
158.5
作者：
Yang, Wenying;Lu, Juming;He, Jiang
通讯作者：
He, Jiang
影响因子：
16.2
作者：
Pan, XR;Li, GW;Howard, BV
通讯作者：
Howard, BV
影响因子：
4.1
作者：
Evans, Josie M. M.;Eades, Claire E.;Leese, Graham P.
通讯作者：
Leese, Graham P.