Behavioral and P3 amplitude enhancement in schizophrenia following feedback training
Behavioral and P3 amplitude enhancement in schizophrenia following feedback training
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反馈训练后精神分裂症的行为和 P3 振幅增强
DOI：
10.1016/s0920-9964(97)00028-5
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发表时间：
1997
影响因子：
4.5
通讯作者：
K. Itoh
中科院分区：
文献类型：
--
作者：
M. Fukuda;S. Niwa;K. Hiramatsu;A. Hata;O. Saitoh;S. Hayashida;K. Nakagome;A. Iwanami;Tsukasa Sasaki;Hideo Honda;K. Itoh
为明确精神分裂症患者行为和电生理异常的可治疗性，对14例精神分裂症患者和12例年龄匹配的正常对照进行了任务反馈训练前后听觉事件相关电位的命中率、反应时和P3波幅的检测。虽然精神分裂症组和正常对照组训练后三项指标的平均值变化均不显著，但精神分裂症组命中率和反应时的变化与P3波幅变化显著相关(r分别为0.6和−0.58)，而正常对照组则无显著相关。仅精神分裂症组训练前P3波幅变化与P3波幅变化呈正相关(r=−0.6 8)，提示训练对P3波幅明显降低的精神分裂症患者更有效。观察到的训练导致的P3波幅增加可能代表了精神分裂症患者行为缺陷的一个可补救方面的电生理学关联，这可能是非药物治疗的有效性的基础。
In order to clarify the remediability of behavioral and electrophysiological abnormalities in schizophrenia, hit rate, reaction time, and P3 amplitude from auditory event-related potentials were evaluated before and after feedback training of a task in 14 schizophrenics and 12 age-matched normal controls. Although mean changes in the three indices due to the training were nonsignificant in both schizophrenic and normal control groups as a whole, the changes in hit rate and reaction time correlated significantly with the P3 amplitude change in the schizophrenic (r = 0.60 and −0.58, respectively) but not in the normal control group. The P3 amplitude change also correlated with the P3 amplitude before the training only in the schizophrenic group (r = −0.68), suggesting that the training was more effective for the schizophrenic patients with marked P3 amplitude reduction. The observed P3 amplitude increase due to training may represent an electrophysiological correlate of a remediable aspect of behavioral deficits in schizophrenics, which may underlie the effectiveness of nonpharmacological treatments.
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追踪精神病理学中的眼球运动：目标特征的影响。
影响因子：
10.6
作者：
Levin,S;Lipton,RB;Holzman,PS
通讯作者：
Holzman,PS
精神分裂症中的 P3 受到刺激方式、反应要求、药物状态和阴性症状的影响。
影响因子：
--
作者：
Pfefferbaum,A;Ford,JM;White,PM;Roth,WT
通讯作者：
Roth,WT
DOI：
10.1176/ajp.149.1.62
发表时间：
1992
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Michael F. Green;Paul Satz;S. Ganzell;Vaclav Jf
通讯作者：
Michael F. Green;Paul Satz;S. Ganzell;Vaclav Jf
影响因子：
4.8
作者：
Levin,S
通讯作者：
Levin,S
精神分裂症认知缺陷的补救。
DOI：
10.1176/ajp.147.12.1650
发表时间：
1990
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Bellack,AS;Mueser,KT;Morrison,RL;Tierney,A;Podell,K
通讯作者：
Podell,K