Functionalized nanoporous silica for the removal of heavy metals from biological systems: adsorption and application.
Functionalized nanoporous silica for the removal of heavy metals from biological systems: adsorption and application.
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DOI：
10.1021/am100616b
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发表时间：
2010-10
影响因子：
9.5
通讯作者：
Addleman, R. Shane
中科院分区：
文献类型：
--
作者：
Yantasee, Wassana;Rutledge, Ryan D.;Chouyyok, Wilaiwan;Sukwarotwat, Vichaya;Orr, Galya;Warner, Cynthia L.;Warner, Marvin G.;Fryxell, Glen E.;Wiacek, Robert J.;Timchalk, Charles;Addleman, R. Shane
关键词：
表面官能化的纳米多孔二氧化硅，通常被称为自组装单分子层介孔载体（SAMMS），以前已经证明了作为非常有效的重金属吸附剂在一系列的水生和环境系统的能力，这表明它们可以有利地用于生物医学应用，如螯合治疗。在此，我们评估了从生物液体中捕获重金属的表面化学，材料生物相容性的各个方面，以及这些材料作为潜在治疗剂的适用性。在测试的材料中，硫醇官能化的SAMMS被证明最能够从生物溶液中去除选定的重金属（即，血液、尿液等）因此，进一步分析硫醇官能化的SAMMS以评估材料在许多不同的生物学相关条件下的性能（即，可变的pH和离子强度），以测量与吸附剂相互作用产生的任何潜在负面影响，如细胞毒性或必需矿物质的去除。此外，细胞摄取研究表明，二氧化硅基材料没有细胞膜渗透，这通常突出了它们保持细胞惰性的能力，因此是无毒的。结果表明，有机配体功能化的纳米多孔二氧化硅可能是一系列解毒疗法和潜在的其他生物医学应用的有价值的材料。
Surface-functionalized nanoporous silica, often referred to as self-assembled monolayers on mesoporous supports (SAMMS), has previously demonstrated the ability to serve as very effective heavy metal sorbents in a range of aquatic and environmental systems, suggesting that they may be advantageously utilized for biomedical applications such as chelation therapy. Herein we evaluate surface chemistries for heavy metal capture from biological fluids, various facets of the materials’ biocompatibility, and the suitability of these materials as potential therapeutics. Of the materials tested, thiol-functionalized SAMMS proved most capable of removing selected heavy metals from biological solutions (i.e., blood, urine, etc.) Consequentially, thiol-functionalized SAMMS was further analyzed to assess the material’s performance under a number of different biologically relevant conditions (i.e., variable pH and ionic strength) to gauge any potentially negative effects resulting from interaction with the sorbent, such as cellular toxicity or the removal of essential minerals. Additionally, cellular uptake studies demonstrated no cell membrane permeation by the silica-based materials generally highlighting their ability to remain cellularly inert and thus nontoxic. The results show that organic ligand functionalized nanoporous silica could be a valuable material for a range of detoxification therapies and potentially other biomedical applications.
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DOI：
10.1124/jpet.102.034728
发表时间：
2002-08-01
影响因子：
3.5
作者：
Bhardwaj, RK;Glaeser, H;Fromm, MF
通讯作者：
Fromm, MF
影响因子：
56.9
作者：
Feng, X;Fryxell, GE;Kemner, KM
通讯作者：
Kemner, KM
影响因子：
14
作者：
Fuller, Jason E.;Zugates, Gregory T.;Langer, Robert S.
通讯作者：
Langer, Robert S.
影响因子：
3.9
作者：
Di Pasqua, Anthony J.;Sharma, Krishna K.;Asefa, Tewodros
通讯作者：
Asefa, Tewodros
影响因子：
6.1
作者：
Grobner, T
通讯作者：
Grobner, T