Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants.
Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants.
复制标题
DOI：
10.1016/j.ebiom.2017.12.016
复制
发表时间：
2018-01
期刊：
影响因子：
11.1
通讯作者：
Black MJ
中科院分区：
文献类型：
--
作者：
Ryan D;Sutherland MR;Flores TJ;Kent AL;Dahlstrom JE;Puelles VG;Bertram JF;McMahon AP;Little MH;Moore L;Black MJ
在正常的人类肾脏发育过程中，肾发生（肾单位的形成）在足月出生时完成，大多数肾单位在妊娠晚期形成。本研究的目的是从形态学角度检查妊娠 20 至 41 周胎儿肾脏的肾发生。肾脏样本是在尸检时从 71 名在子宫内或出生后 24 小时内急性死亡的婴儿身上获得的。使用图像分析，检查肾源区宽度、肾小球代数、肾小体横截面积和肾小球的细胞组成。分别分析女性和男性婴儿的肾脏。胎儿肾脏内形成的肾小球代数与胎龄、体重和肾脏重量成正比，个体之间的最终代数（8 至 12）和肾生成停止时间（一名婴儿在妊娠 37 周时仍在继续）存在差异。从妊娠中期到足月，女性的肾小体横截面积有轻微但显着的增加（r2 = 0.30，P = 0.001），但这在男性中并不明显。成熟肾小球内足细胞、内皮细胞和非上皮细胞的比例在整个妊娠期间保持稳定。这些发现强调了发育中的人类肾脏中肾发生的空间和时间变异性，而肾小球的相对细胞组成似乎不受胎龄的影响。发育中的人类肾脏的肾发生存在空间和时间变异。成熟肾小球的相对细胞组成似乎不受胎龄的影响。妊娠晚期肾小球的生长存在明显的性别二态性。您与生俱来的肾小球（肾脏过滤单位）的数量直接影响您终生的肾脏健康，因此了解它们的形成方式非常重要。在怀孕中期和足月之间，发育中的肾脏中形成的肾小球层数以及肾小球停止形成的时间存在差异，个体之间存在差异。在完全形成的肾小球中，肾小球中不同细胞类型的比例在整个怀孕期间在发育中的肾脏中保持恒定。从怀孕中期到足月，女婴（而非男婴）的肾小球尺寸有所增加。
During normal human kidney development, nephrogenesis (the formation of nephrons) is complete by term birth, with the majority of nephrons formed late in gestation. The aim of this study was to morphologically examine nephrogenesis in fetal human kidneys from 20 to 41 weeks of gestation. Kidney samples were obtained at autopsy from 71 infants that died acutely in utero or within 24 h after birth. Using image analysis, nephrogenic zone width, the number of glomerular generations, renal corpuscle cross-sectional area and the cellular composition of glomeruli were examined. Kidneys from female and male infants were analysed separately. The number of glomerular generations formed within the fetal kidneys was directly proportional to gestational age, body weight and kidney weight, with variability between individuals in the ultimate number of generations (8 to 12) and in the timing of the cessation of nephrogenesis (still ongoing at 37 weeks gestation in one infant). There was a slight but significant (r2 = 0.30, P = 0.001) increase in renal corpuscle cross-sectional area from mid gestation to term in females, but this was not evident in males. The proportions of podocytes, endothelial and non-epithelial cells within mature glomeruli were stable throughout gestation. These findings highlight spatial and temporal variability in nephrogenesis in the developing human kidney, whereas the relative cellular composition of glomeruli does not appear to be influenced by gestational age. There is spatial and temporal variability in nephrogenesis in the developing human kidney. The relative cellular composition of mature glomeruli does not appear to be influenced by gestational age. There is apparent sexual dimorphism in the growth of glomeruli during late gestation. The number of glomeruli (filtering units of the kidneys) you are born with directly influences your life-long kidney health, therefore it is important to understand how they are formed. Between mid-pregnancy and term, there was variability between individuals in relation to the number of layers of glomeruli formed in the developing kidney, and variation in the timing of when they stopped being formed. In fully-formed glomeruli, the proportion of the different cell types in glomeruli remained constant within the developing kidneys throughout pregnancy. Female infants, but not males, exhibited an increase in the size of glomeruli from mid-pregnancy to term.
登录
查看更多内容
DOI：
10.1152/ajprenal.00165.2014
发表时间：
2014-11-01
影响因子：
4.2
作者：
Crobe, A.;Desogus, M.;Faa, G.
通讯作者：
Faa, G.
影响因子：
2.5
作者：
dos Santos, Aline Mara;Fonseca Ferraz, Mara Lucia;da Cunha Castro, Eumenia Costa
通讯作者：
da Cunha Castro, Eumenia Costa
DOI：
10.1111/j.1365-2818.1993.tb03356.x
发表时间：
1993-07-01
期刊：
JOURNAL OF MICROSCOPY-OXFORD
影响因子：
--
作者：
NYENGAARD, JR;MARCUSSEN, N
通讯作者：
MARCUSSEN, N
影响因子：
5.1
作者：
Potter, EL;Thierstein, ST
通讯作者：
Thierstein, ST
影响因子：
2.7
作者：
Hartman, Heather A.;Lai, Hsiao L.;Patterson, Larry T.
通讯作者：
Patterson, Larry T.