Longitudinal analysis of SARS-CoV-2 antibodies in 8000 U.S. first-time convalescent plasma donations.
Longitudinal analysis of SARS-CoV-2 antibodies in 8000 U.S. first-time convalescent plasma donations.
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DOI：
10.1111/trf.16291
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发表时间：
2021-04
期刊：
影响因子：
2.9
通讯作者：
Kreil TR
中科院分区：
文献类型：
--
作者：
Karbiener M;Farcet MR;Ilk R;Schreiner J;Lenart J;Powers N;Stewart JM;Tallman H;Kreil TR
2019冠状病毒病（COVID-19）康复期个体携带针对严重急性呼吸道综合征冠状病毒2（SARS-CoV-2）的抗体，通过血浆捐赠，可用作直接输血或生产超免疫球蛋白（HIG）的潜在治疗药物。这种干预措施的成功取决于这些血浆捐赠中的抗体效力，但目前关于收集有效单位的信息很少。从2020年4月至9月从首次美国COVID-19恢复期血浆供体中收集的共计8749个血浆单位，通过Abbott荧光微粒子免疫测定法（CMIA）表征了SARS-CoV-2免疫球蛋白G（IgG）抗体。根据获得的信号（指数S/C）评价COVID-19发病至献血和献血者年龄、种族、性别和COVID-19严重程度之间的时间。在调查的血浆采集期间，观察到平均指数S/C显著下降，这与平均血浆供体年龄（p <.0001; R2 =.726）和从住院的COVID-19恢复期患者中获得的献血百分比（p =.001; R2 =.4426）的下降显著相关。从需要住院治疗的COVID-19患者、高龄供体和黑人/非洲裔/西班牙裔美国人与白色/高加索人种族中恢复后不久获得了最高滴度血浆单位，而供体性别对Abbott CMIA获得的值无影响。自疫情爆发以来，美国首次COVID-19恢复期血浆捐献者的平均SARS-CoV-2 IgG值显著下降，主要是由于年龄逐渐变小的捐献者的COVID-19严重程度较低。
Coronavirus disease 2019 (COVID‐19) convalescent individuals carry antibodies against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) that, through a plasma donation, can be used as a potential therapeutic either in direct transfusion or for the manufacture of hyperimmune globulin (HIG). The success of such interventions depends on the antibody potency in such plasma donations, but little information on the collection of potent units is currently available. A total of 8749 plasma units, collected from April until September 2020 from first‐time U.S. COVID‐19 convalescent plasma donors, were characterized for SARS‐CoV‐2 immunoglobulin G (IgG) antibodies by Abbott chemiluminescent microparticle immunoassay (CMIA). The period between COVID‐19 onset until donation and donor age, ethnicity, sex, and COVID‐19 severity were evaluated against the obtained signal (index S/C). A marked decrease in mean index S/C was seen over the plasma collection period surveyed, which was significantly correlated to decreases in mean plasma donor age (p < .0001; R2 = .726) and percentage of donations obtained from COVID‐19 convalescent patients who had been hospitalized (p = .001; R2 = .4426). The highest titer plasma units were obtained soon after convalescence from COVID‐19 patients who required hospitalization, from advanced age donors, and from Black/African/Hispanic American versus White/Caucasian ethnicities, whereas there was no effect of donor sex on the values obtained with the Abbott CMIA. Since the onset of the pandemic, the average SARS‐CoV‐2 IgG values of first‐time U.S. COVID‐19 convalescent plasma donations have significantly dropped, mainly due to donations from progressively younger aged donors who tend to experience less severe COVID‐19.
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DOI：
10.1007/s10096-004-1271-9
发表时间：
2005-01
期刊：
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
影响因子：
--
作者：
Cheng Y;Wong R;Soo YO;Wong WS;Lee CK;Ng MH;Chan P;Wong KC;Leung CB;Cheng G
通讯作者：
Cheng G
影响因子：
24.8
作者：
Isho B;Abe KT;Zuo M;Jamal AJ;Rathod B;Wang JH;Li Z;Chao G;Rojas OL;Bang YM;Pu A;Christie-Holmes N;Gervais C;Ceccarelli D;Samavarchi-Tehrani P;Guvenc F;Budylowski P;Li A;Paterson A;Yue FY;Marin LM;Caldwell L;Wrana JL;Colwill K;Sicheri F;Mubareka S;Gray-Owen SD;Drews SJ;Siqueira WL;Barrios-Rodiles M;Ostrowski M;Rini JM;Durocher Y;McGeer AJ;Gommerman JL;Gingras AC
通讯作者：
Gingras AC
影响因子：
158.5
作者：
Gudbjartsson, Daniel F.;Norddahl, Gudmundur L.;Stefansson, Kari
通讯作者：
Stefansson, Kari
影响因子：
3.3
作者：
Crawford, Katherine M.;Choi, Karmel;Davis, Kathryn A.;Zhu, Yiwen;Soare, Thomas W.;Smith, Andrew D. A. C.;Germine, Laura;Dunn, Erin C.
通讯作者：
Dunn, Erin C.
影响因子：
39.3
作者：
Chen, Xiangyu;Pan, Zhiwei;Ye, Lilin
通讯作者：
Ye, Lilin