The Seminal Microbiome and Male Factor Infertility.
The Seminal Microbiome and Male Factor Infertility.
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DOI：
10.1007/s11930-020-00273-5
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发表时间：
2020-09
影响因子：
2
通讯作者：
Eleswarapu SV
中科院分区：
文献类型：
--
作者：
Osadchiy V;Mills JN;Mayer EA;Eleswarapu SV
聚焦于过去十年中发表的研究，我们回顾了有关精液微生物组和男性因素不育的文献。我们强调了微生物可能影响生育能力的潜在机制，并强调了这些研究的关键局限性和临床意义。精液微生物组包括代谢和系统发育多样化的微生物组。乳酸菌与正常精液分析参数和生育力相关;厌氧球菌与精液质量呈负相关。这些微生物可能参与与宿主免疫系统的复杂交互作用，从而调节局部和全身炎症反应，影响精液质量。研究精液微生物组与男性生育力之间的交叉点的研究仍处于起步阶段。最近的调查一直是专门的横截面，相关性研究，限制了已发表的研究的临床适用性。有必要采用更复杂的方法进行前瞻性研究。
Focusing on studies published within the last decade, we review the literature on the seminal microbiome and male factor infertility. We highlight potential mechanisms by which microbes may impact fertility and underscore key limitations and clinical implications of these studies. The seminal microbiome encompasses a metabolically and phylogenetically diverse group of microorganisms. Lactobacillus was consistently associated with normal semen analysis parameters and fertility; Anaerococcus was negatively associated with semen quality. These microbes may participate in a complex cross-talk with the host immune system, thereby modulating local and perhaps systemic inflammatory responses, impacting semen quality. Research investigating the intersection between the seminal microbiome and male fertility is still in its infancy. Recent investigations have been exclusively cross-sectional, correlational studies, limiting the clinical applicability of published research. Prospective studies with more sophisticated methodologies are necessary.
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影响因子：
23.4
作者：
Jungwirth, Andreas;Giwercman, Aleksander;Krausz, Csilla
通讯作者：
Krausz, Csilla
DOI：
10.5114/ceji.2015.54596
发表时间：
2015
期刊：
Central-European journal of immunology
影响因子：
--
作者：
Havrylyuk A;Chopyak V;Boyko Y;Kril I;Kurpisz M
通讯作者：
Kurpisz M
影响因子：
6.7
作者：
Liu CM;Osborne BJ;Hungate BA;Shahabi K;Huibner S;Lester R;Dwan MG;Kovacs C;Contente-Cuomo TL;Benko E;Aziz M;Price LB;Kaul R
通讯作者：
Kaul R
DOI：
10.1093/humrep/dey116
发表时间：
2018-07-01
期刊：
Human reproduction (Oxford, England)
影响因子：
--
作者：
Alfano M;Ferrarese R;Locatelli I;Ventimiglia E;Ippolito S;Gallina P;Cesana D;Canducci F;Pagliardini L;Viganò P;Clementi M;Nebuloni M;Montorsi F;Salonia A
通讯作者：
Salonia A
影响因子：
3.7
作者：
Zhou J;Chen L;Li J;Li H;Hong Z;Xie M;Chen S;Yao B
通讯作者：
Yao B