The Yin and Yang of bone morphogenetic proteins in cancer.
The Yin and Yang of bone morphogenetic proteins in cancer.
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DOI：
10.1016/j.cytogfr.2010.06.003
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发表时间：
2010-08
影响因子：
13
通讯作者：
Morris, Rebecca J.
中科院分区：
文献类型：
--
作者：
Singh, Ashok;Morris, Rebecca J.
Bone morphogenetic proteins (BMPs) were first studied as growth factors or morphogens of the transforming growth factor-beta super family. These growth molecules, originally associated with bone and cartilage development, are now known to play important roles in morphogenesis and homeostasis in many other tissues. More recently, significant contributions of BMPs, their receptors, and interacting molecules have been linked to carcinogenesis and tumor progression. On the other hand, BMPs can sometimes play a role as a tumor suppressor. Our report highlights these new roles in the pathogenesis of cancer that may suggest novel targets for therapeutic intervention.
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