Sensitivity Comparison of Surface Plasmon Resonance and Plasmon-Waveguide Resonance Biosensors.
Sensitivity Comparison of Surface Plasmon Resonance and Plasmon-Waveguide Resonance Biosensors.
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DOI：
10.1016/j.snb.2011.04.008
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发表时间：
2011-08-10
影响因子：
8.4
通讯作者：
Cheng, Quan
中科院分区：
文献类型：
--
作者：
Abbas, Abdennour;Linman, Matthew J.;Cheng, Quan
关键词：
等离子体波导的共振（PWR）传感器对于与脂质双层膜内或内部的生物分子相互作用的投资特别有用，许多研究表明他们提供了独特的定性信息，但是与其他表面等离子体共振（SPR）相比，它们的敏感性评估（传感器尚未广泛研究确定和讨论了五种不同的生物传感器设计，以改变折射率，厚度和质量。在所有考虑的分析参数中，比常规SPR敏感的0.5倍。讨论了表面灵敏度的费用。
Plasmon-waveguide resonance (PWR) sensors are particularly useful for investigation of biomolecular interactions with or within lipid bilayer membranes. Many studies demonstrated their ability to provide unique qualitative information, but the evaluation of their sensitivity as compared to other surface plasmon resonance (SPR) sensors has not been broadly investigated. We report here a comprehensive sensitivity comparison of SPR and PWR biosensors for the p-polarized light component. The sensitivity of five different biosensor designs to changes in refractive index, thickness and mass are determined and discussed. Although numerical simulations show an increase of the electric field intensity by 30–35 % and the penetration depth by four times in PWR, the waveguide-based method is 0.5 to 8 fold less sensitive than conventional SPR in all considered analytical parameters. The experimental results also suggest that the increase in the penetration depth in PWR is made at the expense of the surface sensitivity. The physical and structural reasons for PWR sensor limitations are discussed and a general viewpoint for designing more efficient SPR sensors based on dielectric slab waveguides is provided.
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影响因子：
15
作者：
Liu, Ying;Liao, Puhong;Cheng, Quan;Hooley, Richard J.
通讯作者：
Hooley, Richard J.
通过表面等离子体共振对蛋白质毒素的高度敏感检测，其基于生物素化的内联原子转移自由基聚合扩增。
影响因子：
7.4
作者：
Liu Y;Dong Y;Jauw J;Linman MJ;Cheng Q
通讯作者：
Cheng Q
影响因子：
--
作者：
Salamon, Z;Tollin, G
通讯作者：
Tollin, G
影响因子：
3.7
作者：
Tanenbaum, DM;Laracuente, AL;Gallagher, A
通讯作者：
Gallagher, A
影响因子：
8.4
作者：
Toyama, S;Doumae, N;Ikariyama, Y
通讯作者：
Ikariyama, Y