Prevalence and Factors Associated With Fecal Urgency Among Patients With Ulcerative Colitis and Crohn's Disease in the Study of a Prospective Adult Research Cohort With Inflammatory Bowel Disease.
Prevalence and Factors Associated With Fecal Urgency Among Patients With Ulcerative Colitis and Crohn's Disease in the Study of a Prospective Adult Research Cohort With Inflammatory Bowel Disease.
复制标题
溃疡性结肠炎患者和克罗恩病患者在研究前瞻性成人研究队列中与炎症性肠病的前瞻性研究中，患病率和因素与粪便紧急情况有关。
DOI：
10.1093/crocol/otab046
复制
发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
在溃疡性结肠炎（UC）和克罗恩病（CD）患者中，本研究检查了以下内容：粪便紧迫感（以下简称紧迫感）的患病率，紧迫感与炎症性肠病（IBD）症状和粪便钙卫蛋白的相关性，以及幸福感和紧迫感之间的相关性。在这项来自IBD前瞻性成人研究队列的横断面研究中，尿急被分类为无、轻度和中重度。我们使用多项logistic回归分析了尿急的患病率、尿急与IBD症状和粪便钙卫蛋白（在一个子集中）的相关性，以及使用logistic回归分析了幸福感（感觉不舒服vs一般良好）与尿急的相关性。在576例UC患者中，31.4%报告轻度和28.1%中重度尿急。在1330例CD患者中，33.8%报告轻度和31.4%报告中重度尿急。在UC中，中重度尿急与以下因素相关：平均排便次数/天增加[比值比（OR）1.23; 95%置信区间：1.09，1.23]，排便频率相对于正常值增加（OR，9.95; 95% CI：3.21，30.87），直肠出血（OR，3.36; 95% CI：1.79，6.34），中重度腹痛（OR，17.5; 95%CI：5.38，56.89）和钙卫蛋白≥ 250 μg/g（OR，4.36; 95%CI：1.50，12.66）。在CD中，中重度尿急与以下因素相关：平均排便次数/天增加（OR，1.23; 95% CI：1.14，1.34），排便频率相对于正常增加直肠出血（OR，1.77; 95%CI：1.13，2.78）和中重度腹痛（OR，7.52; 95%CI：4.31，13.14）。UC（OR，4.20; 95% CI：1.69，20.40）和CD患者（OR，2.52; 95% CI：1.51，4.22）的健康状况下降与中重度尿急相关。紧迫感是常见的，与症状和生物标志物相关，表明活动性IBD和健康状况下降。
In patients with ulcerative colitis (UC) and Crohn’s disease (CD), this research examined the following: prevalence of fecal urgency (hereafter urgency), association of urgency with inflammatory bowel disease (IBD) symptoms and fecal calprotectin, and association between well-being and urgency. In this cross-sectional study from the Study of a Prospective Adult Research Cohort with IBD, urgency was categorized as none, mild, and moderate-severe. We examined the prevalence of urgency, association of urgency with IBD symptoms and fecal calprotectin (in a subset) using multinomial logistic regression, and association of well-being (not feeling well vs generally well) with urgency using logistic regression. Among 576 UC patients, 31.4% reported mild and 28.1% moderate-severe urgency. Among 1330 CD patients, 33.8% reported mild and 31.4% moderate-severe urgency. In UC, moderate-severe urgency was associated with: increased average bowel movements/day [odds ratio (OR) 1.23; 95% confidence interval: 1.09, 1.23], increased stool frequency relative to normal (OR, 9.95; 95% CI: 3.21, 30.87), rectal bleeding (OR, 3.36; 95% CI: 1.79, 6.34), moderate-severe abdominal pain (OR, 17.5; 95% CI: 5.38, 56.89), and calprotectin ≥ 250 μg/g (OR, 4.36; 95% CI: 1.50, 12.66). In CD, moderate-severe urgency was associated with: increased average bowel movements/day (OR, 1.23; 95% CI: 1.14, 1.34), increased stool frequency relative to normal (OR, 7.57; 95% CI: 3.30, 17.34), rectal bleeding (OR, 1.77; 95% CI: 1.13, 2.78), and moderate-severe abdominal pain (OR, 7.52; 95% CI: 4.31, 13.14). Reduced well-being was associated with moderate-severe urgency in both UC (OR, 4.20; 95% CI: 1.69, 20.40) and CD patients (OR, 2.52; 95% CI: 1.51, 4.22). Urgency was common and associated with symptoms and biomarkers suggesting active IBD and reduced well-being.
登录
查看更多内容
影响因子：
4.9
作者：
Sipponen, Taina;Nuutinen, Hannu;Farkkila, Martti
通讯作者：
Farkkila, Martti
影响因子：
3.1
作者：
DROSSMAN, DA;SANDLER, RS;MCKEE, DC
通讯作者：
MCKEE, DC
影响因子：
3.5
作者：
Singh, Prashant;Takazawa, Eve;Lembo, Anthony
通讯作者：
Lembo, Anthony
IBD患者的疼痛：非常频繁且经常考虑不足。
影响因子：
3.7
作者：
Zeitz J;Ak M;Müller-Mottet S;Scharl S;Biedermann L;Fournier N;Frei P;Pittet V;Scharl M;Fried M;Rogler G;Vavricka S;Swiss IBD Cohort Study Group
通讯作者：
Swiss IBD Cohort Study Group
影响因子：
2.1
作者：
Petryszyn, Pawel W.;Paradowski, Leszek
通讯作者：
Paradowski, Leszek