Auditory object cognition in dementia.
Auditory object cognition in dementia.
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DOI：
10.1016/j.neuropsychologia.2011.06.004
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发表时间：
2011-07
期刊：
影响因子：
2.6
通讯作者：
Warren JD
中科院分区：
文献类型：
--
作者：
Goll JC;Kim LG;Hailstone JC;Lehmann M;Buckley A;Crutch SJ;Warren JD
四种痴呆综合征的非言语听觉对象加工研究受试者使用一种新颖的定制神经心理电池进行评估。不同的痴呆综合征导致不同的听觉处理障碍。证据提供了非言语听觉处理的可分离阶段。痴呆症患者对非语言声音的认知研究相对较少。在这里，我们进行了一项系统的研究，非语言的声音处理的患者群体与典型的痴呆综合征，包括临床诊断的典型遗忘阿尔茨海默氏病（AD; n = 21），进行性非流利性失语（PNFA; n = 5），逻辑缺失性进行性失语（LPA; n = 7）和与颗粒蛋白前体基因突变相关的失语症（GAA; n = 1），以及年龄匹配的健康对照（n = 20）。基于将复杂声音视为“听觉对象”的认知框架，我们设计了一种新的神经心理学电池，以探索听觉对象在早期感知（子对象），对象表征（感知）和语义水平上的认知。除了实验性听觉成套测验外，所有患者均接受外周听觉和一般神经心理功能评估。虽然听觉对象分析的许多方面在患者群体中受损，并受到一般执行（工作记忆）能力的影响，但某些听觉缺陷对特定的痴呆综合征具有一定的特异性。AD患者有不成比例的听觉统觉缺陷，但保留音色处理。PNFA患者的音色和听觉语义加工有明显缺陷，但听觉大小和统觉加工完整。LPA患者有广泛的听觉缺陷，受工作记忆功能的影响。与此相反，GAA患者的听觉功能基本保留，但轻度缺陷的音高方向处理和更严重的缺陷的听觉统觉。研究结果为不同痴呆综合征听觉客体分析的可分离阶段和听觉客体认知受损的可分离特征提供了证据。
► A study of nonverbal auditory object processing in four dementia syndromes. ► Subjects were assessed using a novel, customised neuropsychological battery. ► Different dementia syndromes lead to distinct auditory processing impairments. ► Evidence is provided for separable stages of nonverbal auditory processing. The cognition of nonverbal sounds in dementia has been relatively little explored. Here we undertook a systematic study of nonverbal sound processing in patient groups with canonical dementia syndromes comprising clinically diagnosed typical amnestic Alzheimer's disease (AD; n = 21), progressive nonfluent aphasia (PNFA; n = 5), logopenic progressive aphasia (LPA; n = 7) and aphasia in association with a progranulin gene mutation (GAA; n = 1), and in healthy age-matched controls (n = 20). Based on a cognitive framework treating complex sounds as ‘auditory objects’, we designed a novel neuropsychological battery to probe auditory object cognition at early perceptual (sub-object), object representational (apperceptive) and semantic levels. All patients had assessments of peripheral hearing and general neuropsychological functions in addition to the experimental auditory battery. While a number of aspects of auditory object analysis were impaired across patient groups and were influenced by general executive (working memory) capacity, certain auditory deficits had some specificity for particular dementia syndromes. Patients with AD had a disproportionate deficit of auditory apperception but preserved timbre processing. Patients with PNFA had salient deficits of timbre and auditory semantic processing, but intact auditory size and apperceptive processing. Patients with LPA had a generalised auditory deficit that was influenced by working memory function. In contrast, the patient with GAA showed substantial preservation of auditory function, but a mild deficit of pitch direction processing and a more severe deficit of auditory apperception. The findings provide evidence for separable stages of auditory object analysis and separable profiles of impaired auditory object cognition in different dementia syndromes.
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影响因子：
4.3
作者：
Elliott TM;Theunissen FE
通讯作者：
Theunissen FE
DOI：
10.1111/j.1460-9568.2007.05865.x
发表时间：
2007-11
期刊：
The European journal of neuroscience
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作者：
Golob, E. J.;Ringman, J. M.;Starr, A.
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