The Role of Nutrients in Protecting Mitochondrial Function and Neurotransmitter Signaling: Implications for the Treatment of Depression, PTSD, and Suicidal Behaviors.
The Role of Nutrients in Protecting Mitochondrial Function and Neurotransmitter Signaling: Implications for the Treatment of Depression, PTSD, and Suicidal Behaviors.
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DOI：
10.1080/10408398.2013.876960
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发表时间：
2016-11-17
影响因子：
10.2
通讯作者：
Vitiello B
中科院分区：
文献类型：
--
作者：
Du J;Zhu M;Bao H;Li B;Dong Y;Xiao C;Zhang GY;Henter I;Rudorfer M;Vitiello B
许多研究已经将严重的压力与重度抑郁症（MDD）和自杀行为的发展联系起来。此外，我们实验室和其他实验室最近的临床前研究表明，在啮齿动物中，慢性应激和应激激素皮质醇对大脑中的线粒体功能和膜脂质造成氧化损伤。线粒体通过提供三磷酸腺苷（ATP）、介导脂质和蛋白质合成、缓冲细胞内钙以及调节凋亡和恢复途径在突触神经递质信号传导中发挥关键作用。膜脂质对于中枢神经系统（CNS）功能同样是必不可少的，因为胆固醇、多不饱和脂肪酸和鞘脂形成脂筏区域，脂筏区域是膜上的一种特殊脂质区域，其通过G蛋白偶联受体和离子通道介导神经递质信号传导。低血清胆固醇水平，低抗氧化能力，以及异常的清晨皮质醇水平是与抑郁和自杀行为相关的生物标志物。在这篇综述中，我们总结了营养素可以保护线粒体和脂质在与认知和情感行为相关的神经元回路中免受氧化损伤的方式。这些营养素包括ω3脂肪酸、抗氧化剂（维生素C和锌）、维生素B家族成员（维生素B12和叶酸）和镁。越来越多的数据表明，这些营养素可以增强神经认知功能，并可能对抑郁症和自杀行为有治疗作用。越来越多的研究表明，经常食用这些营养素可能有助于预防易受伤害的个体出现情绪障碍和自杀行为，或者显着增强现有抗抑郁药的治疗效果。这些发现对军人和平民的健康都具有重要意义。
Numerous studies have linked severe stress to the development of major depressive disorder (MDD), and suicidal behaviors. Furthermore, recent preclinical studies from our laboratory and others have demonstrated that in rodents, chronic stress and the stress hormone cortisol has caused oxidative damage to mitochondrial function and membrane lipids in the brain. Mitochondria play a key role in synaptic neurotransmitter signaling by providing adenosine triphosphate (ATP), mediating lipid and protein synthesis, buffering intracellular calcium, and regulating apoptotic and resilience pathways. Membrane lipids are similarly essential to central nervous system (CNS) function, because cholesterol, polyunsaturated fatty acids, and sphingolipids form a lipid raft region, a special lipid region on the membrane that mediates neurotransmitter signaling through G-protein coupled receptors and ion channels. Low serum cholesterol levels, low antioxidant capacity, and abnormal early morning cortisol levels are biomarkers consistently associated with both depression and suicidal behaviors. In this review, we summarize the manner in which nutrients can protect against oxidative damage to mitochondria and lipids in the neuronal circuits associated with cognitive and affective behaviors. These nutrients include ω3 fatty acids, antioxidants (vitamin C and zinc), members of the vitamin B family (Vitamin B12 and folic acid) and magnesium. Accumulating data have shown that these nutrients can enhance neurocognitive function, and may have therapeutic benefits for depression and suicidal behaviors. A growing body of studies suggests the intriguing possibility that regular consumption of these nutrients may help prevent the onset of mood disorders and suicidal behaviors in vulnerable individuals, or significantly augment the therapeutic effect of available antidepressants. These findings have important implications for the health of both military and civilian populations.
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影响因子：
4.2
作者：
BOURRE, JM;FRANCOIS, M;DURAND, G
通讯作者：
DURAND, G
影响因子：
0.6
作者：
Brunner, J;Parhofer, KG;Bronisch, T
通讯作者：
Bronisch, T
影响因子：
6.6
作者：
Bilici, M;Efe, H;Deger, O
通讯作者：
Deger, O
DOI：
10.1126/stke.2252004re5
发表时间：
2004-03-16
期刊：
Science's STKE : signal transduction knowledge environment
影响因子：
--
作者：
Charney, Dennis S;Manji, Husseini K
通讯作者：
Manji, Husseini K
影响因子：
5.8
作者：
Brenner-Lavie, Hanit;Klein, Ehud;Ben-Shachar, Dorit
通讯作者：
Ben-Shachar, Dorit