A role for the heat shock protein-CD91 axis in the initiation of immune responses to tumors.
A role for the heat shock protein-CD91 axis in the initiation of immune responses to tumors.
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DOI：
10.1007/s12026-011-8221-2
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发表时间：
2011-08
影响因子：
4.4
通讯作者：
Binder, Robert Julian
中科院分区：
文献类型：
--
作者：
Pawaria, Sudesh;Messmer, Michelle Nicole;Zhou, Yu Jerry;Binder, Robert Julian
一百多年来，已经确定在携带肿瘤的宿主中经常可以检测到肿瘤特异性免疫应答。这些免疫反应是否能够控制肿瘤的生长受到许多因素的影响。然而，免疫反应首先启动的机制仍然是一个难题。在本章中，我们提出的证据表明，热休克蛋白肽复合物释放的肿瘤细胞是实体负责启动免疫反应。细胞外HSP与其受体CD 91的相互作用是引发免疫应答所必需的。我们认为，HSP-CD 91相互作用的破坏可能是肿瘤阻止产生针对它的免疫反应的一种积极机制。
For over a hundred years, it has been established that tumor-specific immune responses can frequently be detected in the tumor bearing host. Whether or not these immune responses are capable of controlling the growth of the tumor is influenced by many factors. However, the mechanism by which the immune responses are initiated in the first place has remained a dilemma. In this chapter, we present evidence that heat shock protein-peptide complexes released by tumor cells are the entity responsible for initiating the immune responses. Interaction of the extracellular HSP with its receptor CD91 is necessary for priming the immune response. We propose that the disruption of the HSP-CD91 interaction may be an active mechanism by which tumors prevent the generation of immune responses against it.
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