Investigation into Adaptation in Genes Associated with Response to Estrogenic Pollution in Populations of Roach (Rutilus rutilus) Living in English Rivers.
Investigation into Adaptation in Genes Associated with Response to Estrogenic Pollution in Populations of Roach (Rutilus rutilus) Living in English Rivers.
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英国河流中蟑螂（Rutilus rutilus）种群对雌激素污染反应相关基因适应的调查。
DOI：
10.1021/acs.est.0c00957
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发表时间：
2020
影响因子：
11.4
通讯作者：
Hamilton PB
中科院分区：
文献类型：
--
作者：
Hamilton PB
雄性鱼接触废水处理厂（WwTW）中的雌激素物质会导致女性化并降低生殖健康。然而，自给自足的蟑螂（Rutilus rutilus）种群栖息在被雌性污水污染的河流中。在这项研究中，我们通过比较从接受高水平或低水平 WwTW 排放的河流中取样的种群之间单核苷酸多态性 (SNP) 的频率差异，研究这些蟑螂种群是否已经进化出适应雌激素污染的能力。对 465 只蟑螂中因参与雌激素反应而选择的 36 个“候选”基因内的 SNP 以及参考基因中的 120 个 SNP 进行了基因分型。没有证据表明可以选择高度雌激素依赖性的候选基因，包括雌激素受体、芳香酶和卵黄蛋白原。雄激素受体 (ar) 和细胞色素 P450 1A 基因与流域之间和个体人群中等位基因频率的大幅变化有关，但与雌激素污染没有明确的联系。在以污水为主的李河中选择阿塔可能是由于历史上内分泌干扰性农药的污染造成的。至关重要的是，尽管我们的结果表明群体特异性选择，包括与内分泌干扰相关的基因，但没有强有力的证据表明这种选择是由于暴露于雌激素污染而导致的。
Exposure of male fish to estrogenic substances from wastewater treatment works (WwTWs) results in feminization and reduced reproductive fitness. Nevertheless, self-sustaining populations of roach (Rutilus rutilus) inhabit river stretches polluted with estrogenic WwTW effluents. In this study, we examine whether such roach populations have evolved adaptations to tolerate estrogenic pollution by comparing frequency differences in single-nucleotide polymorphisms (SNPs) between populations sampled from rivers receiving either high- or low-level WwTW discharges. SNPs within 36 “candidate” genes, selected for their involvement in estrogenic responses, and 120 SNPs in reference genes were genotyped in 465 roaches. There was no evidence for selection in highly estrogen-dependent candidate genes, including those for the estrogen receptors, aromatases, and vitellogenins. The androgen receptor (ar) and cytochrome P450 1A genes were associated with large shifts in allele frequencies between catchments and in individual populations, but there is no clear link to estrogen pollution. Selection atarin the effluent-dominated River Lee may have resulted from historical contamination with endocrine-disrupting pesticides. Critically, although our results suggest population-specific selection including at genes related to endocrine disruption, there was no strong evidence that the selection resulted from exposure to estrogen pollution.
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影响因子：
4.8
作者：
E. Wilson;F. S. French
通讯作者：
F. S. French
雌激素受体β基因内的单核苷酸多态性与日本牙鲆（Paralichthys olivaceus）的繁殖指数相关。
DOI：
--
发表时间：
2009
期刊：
Comparative Biochemistry and Physiology Part B Comparative Biochemistry
影响因子：
--
作者：
Bao Shi;H. Wen;F. He;S. Dong;Shen Ma;Cai;X. Y. Chen;Jiayun Ren;Zhang;Guoxiong Jin
通讯作者：
Guoxiong Jin
影响因子：
6.4
作者：
Abbas, Sascha;Beckmann, Lars;Ko, Yon-Dschun
通讯作者：
Ko, Yon-Dschun
影响因子：
11.4
作者：
Blanchfield, Paul J.;Kidd, Karen A.;Postma, Lianne D.
通讯作者：
Postma, Lianne D.
影响因子：
7.7
作者：
Excoffier, Laurent;Lischer, Heidi E. L.
通讯作者：
Lischer, Heidi E. L.