Shifts in gamma phase-amplitude coupling frequency from theta to alpha over posterior cortex during visual tasks.

Shifts in gamma phase-amplitude coupling frequency from theta to alpha over posterior cortex during visual tasks.
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DOI:
10.3389/fnhum.2010.00191
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发表时间:
2010
影响因子:
2.9
通讯作者:
Knight RT
Knight RT
中科院分区:
医学3区
文献类型:
--
作者:
Voytek B;Canolty RT;Shestyuk A;Crone NE;Parvizi J;Knight RT

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正在进行的θ(4-8 Hz)和α(8-12 Hz)电生理振荡的相位与高γ(80-150 Hz)振幅相耦合,这表明低频振荡调节局部皮层活动。虽然这种相位振幅耦合(PAC)已被证明在各种任务和皮层区域,它还没有被证明是否任务的需求差异影响区域分布的首选低频耦合到高伽玛。为了解决这个问题,我们研究了两名植入硬膜下皮质电图网格的受试者的多节律θ/α至高γ PAC。我们发现,高伽马振幅耦合到θ和α谷,并表明,在视觉任务,α/高伽马耦合优先增加视觉皮层区域。这些结果表明,低频相位高频振幅耦合调制的行为任务,并可能反映了一种机制之间的通信神经元网络的选择。
The phase of ongoing theta (4–8 Hz) and alpha (8–12 Hz) electrophysiological oscillations is coupled to high gamma (80–150 Hz) amplitude, which suggests that low-frequency oscillations modulate local cortical activity. While this phase–amplitude coupling (PAC) has been demonstrated in a variety of tasks and cortical regions, it has not been shown whether task demands differentially affect the regional distribution of the preferred low-frequency coupling to high gamma. To address this issue we investigated multiple-rhythm theta/alpha to high gamma PAC in two subjects with implanted subdural electrocorticographic grids. We show that high gamma amplitude couples to the theta and alpha troughs and demonstrate that, during visual tasks, alpha/high gamma coupling preferentially increases in visual cortical regions. These results suggest that low-frequency phase to high-frequency amplitude coupling is modulated by behavioral task and may reflect a mechanism for selection between communicating neuronal networks.
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